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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1437452
This article is part of the Research Topic Exploring the New Biomarkers and Clinical Indicators for Diabetes: Insights from Real-World Studies View all 12 articles

Threshold Effect of Physical Exercise on Its Association to Diabetes Mellitus in Short Sleep Population: Evidence from a Nationwide Study

Provisionally accepted
Yanwei You Yanwei You 1Alimjan Ablitip Alimjan Ablitip 1*Yanyu Lin Yanyu Lin 2*Meihua Tang Meihua Tang 3*Wenxuan Qian Wenxuan Qian 4*Danyi Zhang Danyi Zhang 5*Yuanyuan Tong Yuanyuan Tong 6Hao Ding Hao Ding 1*Keshuo Chen Keshuo Chen 1*Jianxiu Liu Jianxiu Liu 1*Xindong Ma Xindong Ma 1*
  • 1 Division of Sports Sience and Physical Education, Tsinghua University, Haidian, China
  • 2 Shanghai University of Sport, Shanghai, Shanghai Municipality, China
  • 3 Shanghai Fire Research Institute of MEM, Shanghai, China
  • 4 Yangzhou University, Yangzhou, Jiangsu Province, China
  • 5 Changzhou University, Changzhou, Jiangsu Province, China
  • 6 China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    The prevalence of diabetes mellitus (DM) is a significant public health concern, especially among individuals with short sleep duration. Understanding the relationship between physical exercise and DM in this population is crucial for developing effective prevention strategies.However, the presence of a potential threshold effect of exercise on DM risk remains unclear.: Using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2018, this population-based study investigated the association between physical exercise and DM in individuals with short sleep duration (no more than 7 hours per night). Weighted logistic regression analyses were conducted, adjusting for demographic and lifestyle factors. Additionally, a two-piecewise linear regression model was employed to identify any threshold effect of exercise on DM risk. Results: This study included 15,092 participants identified with short sleep duration. Demographic characteristics stratified by DM status indicate higher prevalence among certain groups, such as middle-aged and older adults, males, and non-Hispanic Whites. The analysis revealed an inverse association between exercise levels and DM prevalence among the short sleep population. In the fully adjusted model, individuals engaging in sufficient exercise (> 600 MET-minutes/week) exhibited significantly reduced odds of developing DM [OR (95% CI): 0.624(0.527,0.738), p < 0.001]. Furthermore, the segmented regression model identified an inflection point at 2000 METminutes/week, below which a significant correlation between exercise and DM was observed.This study provides evidence of a threshold effect of physical exercise on its association with DM in individuals with short sleep duration. Tailored exercise interventions targeting this population may help mitigate DM risk and improve overall health outcomes. Further research is warranted to validate these findings and explore optimal exercise thresholds for DM prevention strategies.

    Keywords: Diabetes Mellitus, cross-sectinal study, Exercise, threshold effect, Short sleep

    Received: 23 May 2024; Accepted: 07 Aug 2024.

    Copyright: © 2024 You, Ablitip, Lin, Tang, Qian, Zhang, Tong, Ding, Chen, Liu and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Alimjan Ablitip, Division of Sports Sience and Physical Education, Tsinghua University, Haidian, China
    Yanyu Lin, Shanghai University of Sport, Shanghai, 200072, Shanghai Municipality, China
    Meihua Tang, Shanghai Fire Research Institute of MEM, Shanghai, China
    Wenxuan Qian, Yangzhou University, Yangzhou, 225009, Jiangsu Province, China
    Danyi Zhang, Changzhou University, Changzhou, Jiangsu Province, China
    Hao Ding, Division of Sports Sience and Physical Education, Tsinghua University, Haidian, China
    Keshuo Chen, Division of Sports Sience and Physical Education, Tsinghua University, Haidian, China
    Jianxiu Liu, Division of Sports Sience and Physical Education, Tsinghua University, Haidian, China
    Xindong Ma, Division of Sports Sience and Physical Education, Tsinghua University, Haidian, China

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