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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1437386

Associations between cardiovascular health and low thyroid function among US adults: A population-based study

Provisionally accepted
Xiaoxiao Fang Xiaoxiao Fang 1,2Rui Hu Rui Hu 3*Shani Fei Shani Fei 2*Zhiguo Ding Zhiguo Ding 3*Jiuli Zhao Jiuli Zhao 1*Jianwei Shang Jianwei Shang 1*
  • 1 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
  • 2 Beijing University of Chinese Medicine, Beijing, China
  • 3 Department of Thyropathy, Sunsimiao Hospital, Beijing University of Chinese Medicine, Tongchuan, Shaanxi, China

The final, formatted version of the article will be published soon.

    Background: Higher thyroid-stimulating hormone (TSH) amidst normal thyroid hormone (TH) levels may contribute to a negative impact on cardiovascular health (CVH). We sought to probe the associations between Life's Essential 8 (LE8), a newly revised CVH evaluation, and low thyroid function among US adults.The datasets from the 2007-2012 National Health and Nutrition Examination Survey (NHANES) were applied to the study. Low-normal thyroid function and subclinical hypothyroidism (SCH) were both regarded to be low thyroid function. Multivariable logistic regressions were utilized to inquire about the relationship between LE8 and low thyroid function.Results: Among the 6,315 participants (age ≥20 years), 1,375 (21.77%) were ascertained to be low thyroid function. After adjusting possible confounders, a higher LE8 score was linked to a lower probability of experiencing low thyroid function (Odds ratio [OR] for each 10-point increase: 0.923 [95% CI, 0.884-0.964]). A similar correlation was found between the health factors score and low thyroid function (OR for each 10-point increase: 0.905 [95% CI, 0.876-0.935]). Also, scoring better on physical activity (PA), body mass index (BMI), blood lipid, blood glucose (BG), and blood pressure (BP) may be conducive to reducing the rates of low thyroid function. Furthermore, subgroup and sensitivity analyses indicated that the negative correlations were generally robust. Conclusions: The LE8 score and health factors score were nonlinearly and negatively related to the prevalence concerning low thyroid function. Promoting the regulation of optimum CVH levels could work on mitigating the load of low thyroid function and cardiovascular diseases (CVDs).

    Keywords: low thyroid function, Cardiovascular health, Life's Essential 8, NHANES, Crosssectional study

    Received: 28 May 2024; Accepted: 11 Sep 2024.

    Copyright: © 2024 Fang, Hu, Fei, Ding, Zhao and Shang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Rui Hu, Department of Thyropathy, Sunsimiao Hospital, Beijing University of Chinese Medicine, Tongchuan, Shaanxi, China
    Shani Fei, Beijing University of Chinese Medicine, Beijing, China
    Zhiguo Ding, Department of Thyropathy, Sunsimiao Hospital, Beijing University of Chinese Medicine, Tongchuan, Shaanxi, China
    Jiuli Zhao, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
    Jianwei Shang, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.