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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Bone Research
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1436203
This article is part of the Research Topic The Endocrine Role of the Musculoskeletal System View all 8 articles

Causal Relationship between Sarcopenia and Rotator Cuff Tears: A Mendelian Randomization Study

Provisionally accepted
DONGMEI YANG DONGMEI YANG 1,2*Zheng Li Zheng Li 1Ziqing Jiang Ziqing Jiang 3Xianzhong Mei Xianzhong Mei 1Daguang Zhang Daguang Zhang 4Qiu-Shi Wei Qiu-Shi Wei 5,6
  • 1 Shenzhen Pingle Orthopedics Hospital(Pingshan District Hospital of Traditional Chinese Medicine）, Shenzhen, China
  • 2 Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
  • 3 School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
  • 4 Bethune First Hospital of Jilin University, Changchun, Hebei Province, China
  • 5 Guangdong Research Institute for Orthopedics and Traumatology of Chinese Medicine, The Third Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China
  • 6 The Third Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China

The final, formatted version of the article will be published soon.

    Background Sarcopenia and rotator cuff tears are common among elderly patients.However, the role of sarcopenia in the management of rotator cuff tears has been often overlooked. This study aimed to elucidate the effects of sarcopenia-related traits on rotator cuff tears.Methods Two-sample Mendelian randomization (MR) analyses based on genome-wide association study data were used to evaluate the causal relationships among appendicular lean mass (ALM), usual walking pace, low hand grip strength, and rotator cuff tears. Multivariate Mendelian randomization (MVMR) analyses were used to evaluate the direct effects of each muscle trait on the causal relationship.Univariate MR analysis showed that ALM and usual walking pace were causally related to rotator cuff tears (odds ratio (OR) = 0.895; 95% confidence interval (CI), 0.758-0.966, P<0.001 and OR = 0.458, 95% CI, 0.276-0.762, P = 0.003, respectively), and there was no evidence of causality between low hand grip strength and rotator cuff tears (OR = 1.132, 95% CI, 0.913-1.404, P = 0.26). MVMR analysis confirmed the causal effects of ALM and walking pace on rotator cuff tears (OR = 0.918, 95% CI, 0.851-0.990, P = 0.03 and OR = 0.476, 95% CI, 0.304-0.746, P = 0.001, respectively).A causal genetic relationship exists between sarcopenia and rotaror cuff tears. Sarcopenia-related traits including low muscle mass and physical function, increase the risk of rotaror cuff tears. These findings provide new clinical insights and evidence-based medicine to optimize management of rotaror cuff tears.

    Keywords: causal relationship, Rotator cuff tears, Sarcopenia, genetic epidemiology, Skeletal muscle disease

    Received: 21 May 2024; Accepted: 26 Sep 2024.

    Copyright: © 2024 YANG, Li, Jiang, Mei, Zhang and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: DONGMEI YANG, Shenzhen Pingle Orthopedics Hospital(Pingshan District Hospital of Traditional Chinese Medicine）, Shenzhen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.