Skip to main content

ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Renal Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1434299

Association between serum methylmalonic acid and chronic kidney disease in adults: A cross-sectional study from NHANES 2013-2014

Provisionally accepted
Zufa Zhang Zufa Zhang 1,2Long Lv Long Lv 1,3Sheng Guan Sheng Guan 1,3Fengze Jiang Fengze Jiang 1,3Danni He Danni He 1,3Hongxuan Song Hongxuan Song 1,3Weibing Sun Weibing Sun 1,3Sixiong Jiang Sixiong Jiang 1,3*Feng Tian Feng Tian 1,3*
  • 1 Department of Urology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China
  • 2 Zhongshan Clinical Collage of Dalian University, dalian, China
  • 3 Key Laboratory of Microenvironment Regulation and Immunotherapy of Urinary Tumors of Liaoning Province, Dalian, China

The final, formatted version of the article will be published soon.

    Introduction: Chronic kidney disease(CKD) is a global medical problem. Serum methylmalonic acid(MMA) is a serum marker associated with many diseases. This study aimed to investigate the association between MMA and CKD.Methods: Data from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 were downloaded and analyzed. The association between MMA and CKD was confirmed by using multiple logistic regression modeling. The smooth curve fitting method was used to investigate the nonlinear relationship between them. Subgroup analyses and interaction tests were used to verify the stability of the association between different subgroups. Threshold effect analysis was used to determine the optimal control point for MMA.Results: There was a unique W-shaped nonlinear relationship between MMA and the risk of CKD, with a positive correlation between them (OR=1.66,95% CI:1.27, 2.17; P=0.0002). As the stage of CKD progressed, MMA levels increased. Age, hypertension, and serum vitamin B 12 had significant influences on the association between MMA and the risk of CKD.Our findings revealed that serum MMA accumulation was positively associated with the risk of CKD. Serum MMA level may be a novel index to predict the development and course of CKD. This study may help in the early identification of people at risk for chronic kidney disease and provide new ideas and approaches for prevention and treatment.

    Keywords: Serum methylmalonic acid 1, Chronic kidney disease 2, NHANES 3, risk 4, association 5

    Received: 17 May 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Zhang, Lv, Guan, Jiang, He, Song, Sun, Jiang and Tian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Sixiong Jiang, Department of Urology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China
    Feng Tian, Department of Urology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.