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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Endocrinology of Aging
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1433805
This article is part of the Research Topic Hormones and Aging related diseases View all 4 articles

The Genetic Causal Effect of Hand Grip Strength on Osteoporosis and Falling Risk: A Mendelian Randomization Study

Provisionally accepted
Yanhua Ma Yanhua Ma Jingtao Qiao Jingtao Qiao Zhenxing Wang Zhenxing Wang Qi Pan Qi Pan Lixin Guo Lixin Guo *
  • Beijing Hospital, Peking University, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Background: Patients with osteoporosis (OP) are often associated with decreased hand grip strength and increased risk of falling. It remains unclear whether there is a genetic causal between hand grip strength and OP, falling risk. Methods: The Mendelian randomization study was used to investigate the genetic causal effect of low hand grip strength on total body bone mineral density (BMD) at different ages, OP, and falling risk. Genes for low hand grip strength, total body BMD at different ages, OP, and falling risk were obtained from published genome-wide association studies. Inverse variance weighted, MR‐Egger, and weighted median were applied to perform the MR analysis. The Cochran's Q test, MR‐Egger intercept test, MR-PRESSO global test, and leave-one-out analysis were used to detect the pleiotropy or heterogeneity. Results: The results showed strong evidence that low hand grip strength was positively associated with OP (OR: 1.006, 95% CI: 1.003-1.010; P= 0.0001) and falling risk (OR: 1.069, 95% CI: 1.013-1.129; P= 0.0160), and could not directly affect the different ages of total body BMD (P> 0.05). There was no heterogeneity or horizontal pleiotropy in the sensitivity analysis (all P> 0.05). Conclusion: The study found a positive causal relationship between low hand grip strength and higher risk of OP and falling, which should be taken into account in the development of future prevention and screening strategies for OP and falling.

    Keywords: Hand grip strength, Osteoporosis, Falling risk, Single nucleotide polymorphisms, Mendelian randomization

    Received: 16 May 2024; Accepted: 10 Sep 2024.

    Copyright: © 2024 Ma, Qiao, Wang, Pan and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lixin Guo, Beijing Hospital, Peking University, Beijing, 100730, Beijing Municipality, China

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