Skip to main content

ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1433624
This article is part of the Research Topic Fertility Issues in Congenital and Acquired Lifelong Urogenital Conditions in the Pediatric Population View all 5 articles

Common Mental Disorders and Risk of Female Infertility: A Two-sample Mendelian Randomization Study

Provisionally accepted
Di Mao Di Mao 1Mingmei Lin Mingmei Lin 2Rong Li Rong Li 2*
  • 1 Health Science Centre, Peking University, Beijing, Beijing Municipality, China
  • 2 Peking University Third Hospital, Haidian, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Female infertility is a global issue that impacts on public health seriously and many mental disorders are observed in infertility groups. To investigate the casual relationship between those, genome-wide association studies summary data of anxiety disorder (n=9,897), broad depression (n=322,580), major depressive disorder (n=480,359 and n=500,199), bipolar disorder (n=51,710), insomnia (n= 462,341), and female infertility (n=126,342) were extracted from the existing datasets and was analyzed through the two-sample mendelian randomization study. The following heterogeneity and sensitivity test were applied to ensure the robustness of results. Based on inverse variance weighted results, major depressive disorder was associated with female infertility (P = 0.0001, odds ratio 1.396, 95 % confidence interval 1.175-1.658). No causal relationship was identified between the other four mental disorders and infertility. was found. Additionally, reverse mendelian randomization did not indicate a causal relationship among these disorders. Consequently, the early identification and management of anxiety symptoms in women of reproductive age, in conjunction with the effective treatment of major depressive disorder, may be crucial for preserving female fertility.Thus, managing major depressive disorder may play a critical role in both preventing and treating female infertility.

    Keywords: Mental Disorders, Major Depressive Disorder, Female infertility, Mendelian randomization, Genome-Wide Association Study

    Received: 16 May 2024; Accepted: 16 Sep 2024.

    Copyright: © 2024 Mao, Lin and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Rong Li, Peking University Third Hospital, Haidian, 100191, Beijing Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.