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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Pediatric Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1431984
This article is part of the Research Topic Insights in Pediatric Endocrinology: 2024 View all 8 articles

Conditional Associations of Sex Steroid Hormones with C -Reactive Protein Levels in American Children and Adolescents: Evidence from NHANES 2015-2016

Provisionally accepted
Zhisheng Zhu Zhisheng Zhu Xin-Gong Lin Xin-Gong Lin *Chao-Yang Wang Chao-Yang Wang *Shi-Ze Zhu Shi-Ze Zhu *Xianying Zhou Xianying Zhou *
  • The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China

The final, formatted version of the article will be published soon.

    The relationship between sex steroid hormones and high -sensitivity C-reactive protein(hs-CRP) levels in American children and adolescents is understudied. This research will examine this association.: The study conducted a data analysis from the National Health and Nutrition Examination Survey (NHANES) 2015 -2016, adjusting multiple linear regression models with R 4.2.2 and EmpowerStats. A total of 1,768 children and adolescents were surveyed.Data collection involved measurements of serum levels of testosterone, estradiol, sex hormone -binding globulin (SHBG) and hs -CRP.Results:With the increase in testosterone, a brief rise ( β=0.082, P=0.047) followed by an overall decline ( β=-0.028, P=0.023) in hs-CRP was observed in the Male Prepubertal population, while a continuous decline ( β=-0.002, P<0.05) was seen in the Male Pubertal group. A positive correlation ( β=0.047, P<0.05) was found between testosterone and hs -CRP in the Female Prepubertal population, whereas no significant association ( β=0.002, P>0.05) was detected in the Female Pubertal group. A significant inverse corre lation was observed between estradiol and hs-CRP solely in the Female Pubertal group ( β=-0.002, P<0.05), while no association was found in other populations. An inverse relationship between SHBG and hs-CRP was consistently noted across all groups: Male Prepubertal, Male Pubertal, Female Prepubertal, and Female Pubertal.The association between sex steroid hormones and high -sensitivity C-reactive protein (hs-CRP) levels among American children and adolescents is conditional and influenced by multiple factors.

    Keywords: Children, adolescents, NHANES, sex steroid hormones, C -reactive protein children, C -Reactive protein

    Received: 13 May 2024; Accepted: 26 Aug 2024.

    Copyright: © 2024 Zhu, Lin, Wang, Zhu and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xin-Gong Lin, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
    Chao-Yang Wang, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
    Shi-Ze Zhu, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
    Xianying Zhou, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China

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