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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1430693

Microwave ablation for lymph node metastasis in thyroid cancer：the impact of lymph node diameter

Provisionally accepted
Xiaoyi Xiao Xiaoyi Xiao 1Xi CHEN Xi CHEN 2Pei Li Pei Li 1*Yun Zhu Yun Zhu 3*
  • 1 Third Xiangya Hospital, Central South University, Changsha, China
  • 2 School of Nursing, Faculty of Health and Social Sciences, Hong Kong Polytechnic University, Kowloon, Hong Kong, SAR China
  • 3 Department of Ultrasound, The First Hospital of Hunan University of Chinese Medicine, Changsha, Anhui Province, China

The final, formatted version of the article will be published soon.

    Objectives: To explore the impact of lymph node diameter on the efficacy and safety of ultrasoundguided microwave ablation (MWA) in the treatment of cervical metastatic lymph nodes (CMLNs) from thyroid cancer.Methods: A total of 32 patients with 58 CMLNs from thyroid cancer underwent ultrasound-guided MWA and were included in the retrospective study. Patients were divided into three groups based on the mean largest diameter of the CMLNs: Group A (diameter ≤10mm), Group B (10mm < diameter ≤20mm), and Group C (diameter >20mm). The research involved comparing changes in cervical metastatic lymph nodes and serum thyroglobulin (sTg) levels, as well as the incidence of complications, before and after microwave ablation across three groups of patients.The technical success rate of this study was 100% (32/32), and they showed no major complications. Compared with measurements taken before MWA, the mean largest diameter and volume of CMLNs, as well as the sTg level, showed significant reductions (p <0.05) at the last follow-up in all three patient groups. Group A and B exhibited higher lymph node volume reduction rates and complete disappearance rates compared to Group C. However, the recurrence rate in the three groups were in the following order: Group C > Group B > Group A. The occurrence rate of mild complications was Group A > Group C > Group B.MWA is a safe and effective method for treating CMLNs, with advantages for localized nodes but limitations for larger ones. Careful consideration and personalized plans are advised, based on comprehensive evidence assessment.

    Keywords: Microwave ablation, Lymph Node, Papillary thyroid carcinoma, ultrasound, metastasis

    Received: 10 May 2024; Accepted: 19 Jul 2024.

    Copyright: © 2024 Xiao, CHEN, Li and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Pei Li, Third Xiangya Hospital, Central South University, Changsha, China
    Yun Zhu, Department of Ultrasound, The First Hospital of Hunan University of Chinese Medicine, Changsha, Anhui Province, China

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