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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1430321
This article is part of the Research Topic Maternal Factors and Vascular Remodelling in Pregnancy View all 3 articles

Impact of endometrial thickness and its combined effect with maternal age on singleton adverse neonatal outcomes in frozen-thawed embryo transfer cycles

Provisionally accepted
Jie Wang Jie Wang *Lina Gao Lina Gao *Qiaoyun Huang Qiaoyun Huang *Weihua Jiang Weihua Jiang *Linjun Chen Linjun Chen *Shanshan Wang Shanshan Wang *
  • Nanjing Drum Tower Hospital, Nanjing, China

The final, formatted version of the article will be published soon.

    Background: Thin endometrial thickness (EMT) and advanced age are both common risk factors for adverse neonatal outcomes (ANOs). However, studies evaluating the impact of EMT and combined effect of EMT and age on ANOs remain scarce with conflicts.Method: A retrospective cohort study was conducted on 7,715 singleton deliveries from frozen embryo transfer (FET) cycles between 2017 and 2021. The participants were categorized into four groups based on EMT quartiles (≤8.5 mm, 8.6-9.5 mm, 9.6-10.5 mm, >10.5 mm). The primary outcome was preterm birth (PTB), and secondary outcome included early PTB (EPTB), small/large for gestational age (SGA/LGA), low birth weight (LBW).Results: Baseline characteristics were unevenly distributed across EMT groups. After adjusting for the confounders, EMT was found to be associated with the incidence of PTB (aOR 0.922, 95% CI 0.874-0.973, p = 0.003), EPTB (aOR 0.795, 95% CI 0.663-0.954, p = 0.014), LBW (aOR 0.886, 95% CI 0.796-0.986, p = 0.027) and LGA (aOR 1.038, 95% CI 1.004-1.074, p = 0.030). Furthermore, the rates of LBW in the group of EMT at 9.6-10.5 mm (aOR 0.551, 95% CI 0.339-0.895, p = 0.016) and >10.5 mm (aOR 0.536, 95% CI 0.332-0.865, p = 0.011) were lower compared to those with EMT ≤8.5 mm. Among women aged over 35, EMT of 9.6-10.5 mm was associated with a significantly lower incidence of LBW compared to thinner EMT, without increasing the risk of ANOs related to thicker EMT.Our study demonstrated with the independent nonlinear impact of EMT on PTB, EPTB, LGA, and LBW. It provided new insights into the combined effects of EMT and age in FET cycles, and offered valuable references for the clinical management and treatment strategies aimed 2 at EMT.

    Keywords: Frozen-thawed embryo transfer, singleton delivery, Endometrial thickness, Maternal Age, Adverse neonatal outcomes

    Received: 09 May 2024; Accepted: 13 Dec 2024.

    Copyright: © 2024 Wang, Gao, Huang, Jiang, Chen and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jie Wang, Nanjing Drum Tower Hospital, Nanjing, China
    Lina Gao, Nanjing Drum Tower Hospital, Nanjing, China
    Qiaoyun Huang, Nanjing Drum Tower Hospital, Nanjing, China
    Weihua Jiang, Nanjing Drum Tower Hospital, Nanjing, China
    Linjun Chen, Nanjing Drum Tower Hospital, Nanjing, China
    Shanshan Wang, Nanjing Drum Tower Hospital, Nanjing, China

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