AUTHOR=Liu Jianning , Feng Zhuoying , Gao Ru , Liu Peng , Meng Fangang , Fan Lijun , Liu Lixiang , Du Yang 

TITLE=Analysis of risk factors for papillary thyroid carcinoma and the association with thyroid function indicators

JOURNAL=Frontiers in Endocrinology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1429932

DOI=10.3389/fendo.2024.1429932

ISSN=1664-2392

ABSTRACT=<sec><title>Objective</title><p>This study aims to analyze the relationship between papillary thyroid carcinoma (PTC) and various factors.</p></sec><sec><title>Methods</title><p>The study involved two groups—PTC patients and non-PTC controls. We utilized binary logistic regression and Least Absolute Shrinkage and Selection Operator (Lasso) regression for variable selection and risk factor analysis. Correlation analysis was performed using Spearman’s rank correlation. The diagnostic value of thyroid stimulating hormone (TSH) levels for PTC was assessed using Receiver Operating Characteristic (ROC) curves.</p></sec><sec><title>Results</title><p>PTC patients exhibited higher body mass index (BMI) (23.71 vs. 22.66, p&lt;0.05) and TSH levels (3.38 vs. 1.59, p&lt;0.05). Urinary iodine concentration (UIC) was an independent predictor of PTC (OR=1.005, p&lt;0.05). The optimal TSH threshold for PTC diagnosis was 2.4 mIU/L [The Area Under the Curve (AUC)=67.3%, specificity=71.4%, sensitivity=70.1%]. TSH levels positively correlated with BMI (r=0.593, p&lt;0.05) and UIC (r=0.737, p&lt;0.05).</p></sec><sec><title>Conclusions</title><p>UIC may be an independent predictor of PTC, and TSH levels have some diagnostic value for identifying PTC.</p></sec>