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REVIEW article

Front. Endocrinol.
Sec. Bone Research
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1429567

The Role of Clec11a in Bone Construction and Remodeling

Provisionally accepted
Ke Xu Ke Xu Rui-Qi Huang Rui-Qi Huang *Ruiming Wen Ruiming Wen Yao Yang Yao Yang *Bo Chang Bo Chang *Xuejie Yi Xuejie Yi *
  • Shenyang Sport University, Shenyang, China

The final, formatted version of the article will be published soon.

    Bone is a dynamically active tissue whose health status is closely related to its construction and remodeling, and imbalances in bone homeostasis lead to a wide range of bone diseases. The sulfated glycoprotein C-type lectin structural domain family 11 member A (Clec11a) is a key factor in bone mass regulation that significantly promotes the osteogenic differentiation of bone marrow mesenchymal stem cells and osteoblasts and stimulates chondrocyte proliferation, thereby promoting longitudinal bone growth. More importantly, Clec11a has high therapeutic potential for treating various bone diseases and can enhance the therapeutic effects of the parathyroid hormone against osteoporosis. Clec11a is also involved in the stress/adaptive response of bone to exercise via mechanical stimulation of the cation channel Pieoz1. Clec11a plays an important role in promoting bone health and preventing bone disease and may represent a new target and novel drug for bone disease treatment. Therefore, this review aims to explore the role and possible mechanisms of Clec11a in the skeletal system, evaluate its value as a potential therapeutic target against bone diseases, and provide new ideas and strategies for basic research on Clec11a and preventing and treating bone disease.

    Keywords: Clec11a, Skeletal system, Bone construction, Bone Remodeling, Exercise

    Received: 08 May 2024; Accepted: 25 Jul 2024.

    Copyright: © 2024 Xu, Huang, Wen, Yang, Chang and Yi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Rui-Qi Huang, Shenyang Sport University, Shenyang, China
    Yao Yang, Shenyang Sport University, Shenyang, China
    Bo Chang, Shenyang Sport University, Shenyang, China
    Xuejie Yi, Shenyang Sport University, Shenyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.