Skip to main content

SYSTEMATIC REVIEW article

Front. Endocrinol.
Sec. Cancer Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1429165
This article is part of the Research Topic Endocrine Aspects of Gynaecological Cancers, volume II View all 3 articles

Causal relationship between genetically predicted uterine leiomyoma and cancer risk: A two-sample Mendelian randomization

Provisionally accepted
Chenyang Zhao Chenyang Zhao 1*Anquan Shang Anquan Shang 2Han Wu Han Wu 3Qiong Li Qiong Li 1Lixiu Peng Lixiu Peng 1Chaoyan Yue Chaoyan Yue 4
  • 1 The First People's Hospital of Chenzhou, Chenzhou, China
  • 2 Second People's Hospital of Lianyungang, Lianyungang, Jiangsu Province, China
  • 3 School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai Municipality, China
  • 4 Obstetrics and Gynecology Hospital, Fudan University, Shanghai, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

    Purpose: Studies have demonstrated that hormonal imbalance, including increased estrogen or decreased progesterone were the main inducing factor of uterine leiomyoma (UL) development and some cancers. UL has been reported to be ralated with several cancers in observational studies.However, the casual assocciations between UL and cancers remain unclear.We conducted a two-sample Mendelian randomization (MR) analysis to investigate the casual assocciations between UL and 16 site-specific cancers using the public databases. Four methods were applied in our MR analysis, including the inverse variance weighting (IVW), MR-Egger, weighted median and weighted mode. We also performed sensitivity tests to evaluate the robustness of the causal assocciations.Results: IVW analysis showed that genetically predicted uterine leiomyoma were associated with high risk of low malignant potential ovarian cancer (OR = 1.22, 95% CI: 1.06-1.40, p = 0.004), serous

    Keywords: Luojiajing Road, No102, Chenzhou, China Cancer, Casual association, hormone, Mendelian randomization, Uterine leiomyoma

    Received: 07 May 2024; Accepted: 26 Jul 2024.

    Copyright: © 2024 Zhao, Shang, Wu, Li, Peng and Yue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chenyang Zhao, The First People's Hospital of Chenzhou, Chenzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.