AUTHOR=Jiang Wen , Yang Lixia , Liang Shuang 

TITLE=The relationship between sex hormone levels and ocular surface parameters in girls with idiopathic central precocious puberty

JOURNAL=Frontiers in Endocrinology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1429154

DOI=10.3389/fendo.2024.1429154

ISSN=1664-2392

ABSTRACT=<sec><title>Purpose</title><p>The study aimed to investigate the correlation between the change of sex hormone levels and ocular surface parameters in girls with idiopathic central precocious puberty(ICPP).</p></sec><sec><title>Methods</title><p>Eighteen girls with ICPP and 18 age-matched normal girls participated in this study, all of the participants had undergone physical measurements, laboratory tests, imaging examination and ocular surface assessments.</p></sec><sec><title>Results</title><p>The Objective Scatter Index (OSI) in the ICPP group was significantly higher than in the control group (<italic>P</italic> = 0.031), girls with ICPP showed slightly lower MNITBUT compared to the normal control group, although this difference was not statistically significant. Bivariate analysis revealed a positive association between estradiol and OSI (r=0.383, <italic>P</italic>=0.021), Additionally, in the study population, both Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH) were negatively correlated with Mean noninvasive tear breakup time (MNITBUT) (r=-0.359, <italic>P</italic>=0.031)(r=-0.357, <italic>P</italic>=0.032).</p></sec><sec><title>Conclusion</title><p>In comparison with the normal control group, alterations in the OSI were observed in girls with ICPP. This alteration may be associated with an elevation in estrogen levels. Although there was a slight non-significant decrease in NITBUT in ICPP girls, the negative correlation between LH and FSH with MNITBUT suggests new perspective for further investigation.</p></sec>