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REVIEW article

Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1427679

Diabetic peripheral neuropathy based on Schwann cell injury: mechanisms of cell death regulation and therapeutic perspectives

Provisionally accepted
Lijiao Wu Lijiao Wu 1,2Xiang Jin Wang Xiang Jin Wang 3Xi Luo Xi Luo 4Jingqi Zhang Jingqi Zhang 1,2Xinyi Zhao Xinyi Zhao 5Qiu Chen Qiu Chen 2*
  • 1 School of Clinical Medicine, Chengdu University of Traditional Chinses Medicine, Chengdu, Sichuan Province, China
  • 2 Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
  • 3 School of Sports Medicine and Health, Chengdu Sport University, Chengdu, Sichuan Province, China
  • 4 Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Liaoning Province, China
  • 5 College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan Province, China

The final, formatted version of the article will be published soon.

    Diabetic peripheral neuropathy (DPN) is a complication of diabetes mellitus that lacks specific treatment, its high prevalence and disabling neuropathic pain greatly affects patients' physical and mental health. Schwann cells (SCs) are the major glial cells of the peripheral nervous system, which play an important role in various inflammatory and metabolic neuropathies by providing nutritional support, wrapping axons and promoting repair and regeneration. Increasingly, high glucose (HG) has been found to promote the progression of DPN pathogenesis by targeting SCs death regulation, thus revealing the specific molecular process of programmed cell death (PCD) in which SCs are disrupted is an important link to gain insight into the pathogenesis of DPN. This paper is the first to review the recent progress of HG studies on apoptosis, autophagy, pyroptosis, ferroptosis and necroptosis pathways in SCs, and points out the crosstalk between various PCDs and the related therapeutic perspectives, with the aim of providing new perspectives for a deeper understanding of the mechanisms of DPN and the exploration of effective therapeutic targets.

    Keywords: Diabetic peripheral neuropathy, Schwann Cells, Hyperglycemia, Programmed Cell Death Regulation, Neuropathic pain (NP)

    Received: 07 May 2024; Accepted: 24 Jul 2024.

    Copyright: © 2024 Wu, Wang, Luo, Zhang, Zhao and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qiu Chen, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.