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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1427207
This article is part of the Research Topic Exploring the New Biomarkers and Clinical Indicators for Diabetes: Insights from Real-World Studies View all 10 articles

Elevated Triglyceride-Glucose Index Associated with Increased Risk of Diabetes in Non-Obese Young Adults: A Longitudinal Retrospective Cohort Study from Multiple Asian Countries

Provisionally accepted
Jian Han Jian Han 1*Weifeng Dai Weifeng Dai 1*Lixia Chen Lixia Chen 1*Zhenhua Huang Zhenhua Huang 2Chengzhi Li Chengzhi Li 1Keke Wang Keke Wang 3*
  • 1 First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China
  • 2 Shenzhen Second People's Hospital, Shenzhen, China
  • 3 The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Objective: Previous studies have confirmed a positive correlation between the Triglyceride-Glucose (TyG) index and future risk of diabetes. However, evidence of this association in non-obese young populations remains limited.This study aims to investigate the relationship between the TyG index and the future risk of diabetes among non-obese young adults.Methods: This retrospective cohort study included 113,509 non-obese young adults from China and 9,549 from Japan. The mean age was 35.73 ± 6.38 years, and 56,469 participants (45.89%) were male. The median follow-up duration was 3.38 years. The association between baseline TyG index and risk of diabetes was examined using Cox proportional hazards regression models. Non-linear relationships between the TyG index and risk of diabetes were identified using cubic splines and smoothed curve fitting in the Cox models. Sensitivity and subgroup analyses were also conducted.After adjusting for covariates, the results indicated a positive correlation between the TyG index and risk of diabetes in non-obese young adults (HR=3.57, 95% CI: 2.92-4.36, P＜0.0001). A non-linear relationship was observed with an inflection point at 7.3. The HR to the right of this inflection point was 3.70 (95% CI: 3.02-4.52, P＜0.0001), while to the left, it was 0.34 (95% CI: 0.06-1.88, P=0.2161). The robustness of our findings was confirmed through a series of sensitivity analyses and subgroup analyses.This study reveals a positive and non-linear association between the TyG index and risk of diabetes among non-obese young adults. Interventions aimed at reducing the TyG index by lowering triglycerides or fasting glucose levels could substantially decrease the future likelihood of developing diabetes in this population.

    Keywords: TyG index, Association, diabetes, non-obese young adults, non-linear

    Received: 03 May 2024; Accepted: 24 Jul 2024.

    Copyright: © 2024 Han, Dai, Chen, Huang, Li and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jian Han, First Affiliated Hospital of Jinan University, Guangzhou, 510630, Guangdong Province, China
    Weifeng Dai, First Affiliated Hospital of Jinan University, Guangzhou, 510630, Guangdong Province, China
    Lixia Chen, First Affiliated Hospital of Jinan University, Guangzhou, 510630, Guangdong Province, China
    Keke Wang, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Guangdong Province, China

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