AUTHOR=Pilsova Zuzana , Pilsova Aneta , Zelenkova Natalie , Klusackova Barbora , Chmelikova Eva , Postlerova Pavla , Sedmikova Marketa 

TITLE=Hydrogen sulfide and its potential as a possible therapeutic agent in male reproduction

JOURNAL=Frontiers in Endocrinology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1427069

DOI=10.3389/fendo.2024.1427069

ISSN=1664-2392

ABSTRACT=<p>Hydrogen sulfide (H<sub>2</sub>S) is an endogenously produced signaling molecule that belongs to the group of gasotransmitters along with nitric oxide (NO) and carbon monoxide (CO). H<sub>2</sub>S plays a pivotal role in male reproductive processes. It is produced in various tissues and cells of the male reproductive system, including testicular tissue, Leydig and Sertoli cells, epididymis, seminal plasma, prostate, penile tissues, and sperm cells. This review aims to summarize the knowledge about the presence and effects of H<sub>2</sub>S in male reproductive tissues and outline possible therapeutic strategies in pathological conditions related to male fertility, e. g. spermatogenetic disorders and erectile dysfunction (ED). For instance, H<sub>2</sub>S supports spermatogenesis by maintaining the integrity of the blood-testicular barrier (BTB), stimulating testosterone production, and providing cytoprotective effects. In spermatozoa, H<sub>2</sub>S modulates sperm motility, promotes sperm maturation, capacitation, and acrosome reaction, and has significant cytoprotective effects. Given its vasorelaxant effects, it supports the erection of penile tissue. These findings suggest the importance and therapeutic potential of H<sub>2</sub>S in male reproduction, paving the way for further research and potential clinical applications.</p>