AUTHOR=Yu Siming , Li Chunsheng , Lu Xinxin , Han Zehui , Li Yue , Yuan Xingxing , Guo Dandan 

TITLE=The m6A-ncRNAs axis in diabetes complications: novel mechanism and therapeutic potential

JOURNAL=Frontiers in Endocrinology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1426380

DOI=10.3389/fendo.2024.1426380

ISSN=1664-2392

ABSTRACT=<p>Diabetes, a multifaceted metabolic disorder, poses a significant global health burden with its increasing prevalence and associated complications, such as diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, and diabetic angiopathy. Recent studies have highlighted the intricate interplay between N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) and non-coding RNAs (ncRNAs) in key pathways implicated in these diabetes complications, like cell apoptosis, oxidative stress, and inflammation. Thus, understanding the mechanistic insights into how m<sup>6</sup>A dysregulation impacts the expression and function of ncRNAs opens new avenues for therapeutic interventions targeting the m<sup>6</sup>A-ncRNAs axis in diabetes complications. This review explores the regulatory roles of m<sup>6</sup>A modifications and ncRNAs, and stresses the role of the m<sup>6</sup>A-ncRNA axis in diabetes complications, providing a therapeutic potential for these diseases.</p>