Skip to main content

ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Systems Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1421426

Associations between serum total bilirubin and overactive bladder from the National Health and Nutrition Examination Survey

Provisionally accepted
Jiang Bo Jiang Bo 1Lin Cunbao Lin Cunbao 2Dong Binbin Dong Binbin 1Lu Xiaoming Lu Xiaoming 1Liu Yadong Liu Yadong 3*
  • 1 Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
  • 2 Department of Basic Medical Science, Jiangsu Vocational College of Medicine, Yancheng, China
  • 3 Zhongda Hospital, Southeast University, Nanjing, China

The final, formatted version of the article will be published soon.

    The relationship between serum total bilirubin (STB) concentrations and the risk of overactive bladder (OAB) remains uncertain. This study aims to explore the potential connection between STB and OAB.: We utilized data from the National Health and Nutrition Examination Survey (NHANES) database for the years 2001-2020. Weighted multivariate logistic regression and restricted cubic spline (RCS) analysis assessed the relationship between STB and OAB. Interaction analyses on subgroups were performed to validate the findings.The study included 28,958 participants, with 5,313 identified as having OAB. The results from the fully adjusted models revealed an odds ratio (OR) of 0.98 (95% CI: 0.97, 0.99) and a statistically significant P value of less than 0.001 for the relationship between STB and OAB. Notably, individuals in the second and third tertiles exhibited significant differences compared to those in the lowest STB tertile, with respective odds ratios (P values) of 0.88 (0.04) and 0.80 (<0.001). RCS analysis indicated a non-linear association between STB and OAB (P for nonlinearity = 0.042), with an inflection point at 16.8 μmol/L. The association between STB and OAB exhibited consistency across various subgroups, except for stratification by age and diabetes status(P for interaction = 0.002 and 0.004, respectively ), indicating a stronger correlation in individuals younger than 60 years or those without diabetes.These findings suggest an inverse association between STB concentrations below 16.8 μmol/L and the incidence of OAB. Bilirubin could potentially serve as an intervention or risk assessment tool for OAB in future studies.

    Keywords: overactive bladder, Serum total bilirubin, a population-based study, Risk Assessment, NHANES

    Received: 30 Apr 2024; Accepted: 20 Dec 2024.

    Copyright: © 2024 Bo, Cunbao, Binbin, Xiaoming and Yadong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Liu Yadong, Zhongda Hospital, Southeast University, Nanjing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.