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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1420088

Serum 25-hydroxy vitamin D level is associated with elastography detected liver fibrosis in patients with type 2 diabetes mellitus in China

Provisionally accepted
Xiaodong Wu Xiaodong Wu 1Nan Huang Nan Huang 1Bing Lu Bing Lu 2Weixia Sun Weixia Sun 1Liqin Yao Liqin Yao 3Maoyun Wang Maoyun Wang 4Yao Wang Yao Wang 3Wenxuan Wu Wenxuan Wu 3Yingzhao Liu Yingzhao Liu 5Ting Yang Ting Yang 1Ruidong Gao Ruidong Gao 4Congqing Miao Congqing Miao 6Ling Li Ling Li 1*
  • 1 Zhongda Hospital, Southeast University, Nanjing, China
  • 2 First People's Hospital of Kunshan, Kunshan, Jiangsu, China
  • 3 Yixing Hospital of Traditional Chinese Medicine, wu xi, China
  • 4 Baoying County Traditional Chinese Medicine Hospital, Yangzhou, Jiangsu Province, China
  • 5 Jiangsu University Affiliated People's Hospital, Zhenjiang, Jiangsu Province, China
  • 6 Jiangdu People's Hospital of Yangzhou, Yangzhou, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Objective: In this cross-sectional study including patients with type 2 diabetes mellitus (T2DM) we aimed to explore the relationship between serum 25-hydroxy vitamin (25(OH)D) level and liver steatosis and fibrosis in Chinese population.Patients visiting 16 clinical centers with T2DM were recruited. The status of liver steatosis and fibrosis were then assessed using elastography examination.Associating factors of steatosis and fibrosis were explored using regression analysis.Correlations between serum 25(OH)D levels with other patient characteristics were analyzed using linear regression.Results: Totally 1513 T2DM patients were included in the study period. The prevalence of steatosis and fibrosis were 69.7%, and 34.6%, separately. A lower level of 25(OH)D was detected in patients with liver steatosis compared to those without, although it was not an independent predictor of this condition. However, 25(OH)D level was independently associated with liver fibrosis even when adjusted to age, sex, BMI, HbA1c, insulin, and HOMA-IR (OR = 0.964 [0.935-0.993], P = 0.015). When patients were separated into subgroups of different gender, correlations between 25(OH)D and fibrosis were identified in male group (OR = 0.969 [0.940-0.998], P = 0.038).In conclusion, this multi-center, cross-sectional study in T2DM patients showed that serum 25-hydroxy vitamin D level is strongly associated with liver fibrosis, and this relationship was more pronounced in male patients.

    Keywords: type 2 diabetes mellitus, 25(OH)D, Liver steatosis, liver fibrosis, BMI, body mass index

    Received: 19 Apr 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Wu, Huang, Lu, Sun, Yao, Wang, Wang, Wu, Liu, Yang, Gao, Miao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ling Li, Zhongda Hospital, Southeast University, Nanjing, China

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