Skip to main content

ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1419502
This article is part of the Research Topic Continuous Glucose Monitoring: Beyond Diabetes Management View all 8 articles

Fear of hypoglycemia and sleep in children with type 1 diabetes and their parents Comparing predicted low suspend pump treatment to pump treatment with intermittent glucose monitoring. The QUEST Randomized Crossover Study

Provisionally accepted
Ulrike Schierloh Ulrike Schierloh 1*Gloria A. Aguayo Gloria A. Aguayo 2Muriel Fichelle Muriel Fichelle 1Cindy De Melo Dias Cindy De Melo Dias 1Anna Schritz Anna Schritz 2Michel Vaillant Michel Vaillant 2Katharine Barnard-Kelly Katharine Barnard-Kelly 3Ohad Cohen Ohad Cohen 4Inge Gies Inge Gies 5Carine de Beaufort Carine de Beaufort 1
  • 1 Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg
  • 2 Luxembourg Institute of Health, Luxembourg, Luxembourg
  • 3 Southern Health NHS Foundation Trust, Southampton, United Kingdom
  • 4 Sheba Medical Center, Ramat Gan, Tel Aviv District, Israel
  • 5 Vrije University Brussels, Brussels, Brussels, Belgium

The final, formatted version of the article will be published soon.

    Aims To compare impact of pump treatment and continuous glucose monitoring (CGM) with predictive low glucose suspend (SmartGuard) or user initiated CGM (iscCGM) on sleep and hypoglycemia fear in children with type 1 Diabetes and parents. Methods Secondary analysis of data from 5 weeks pump treatment with iscCGM (A) or SmartGuard (B) open label, single center, randomized cross-over study was performed. At baseline and end of treatment arms, sleep and fear of hypoglycemia were evaluated using ActiGraph and questionnaires. Results 31 children (6-14 years, male: 50%) and 30 parents (28-55 years) participated. Total sleep minutes did not differ significantly for children (B vs. A: -9.27; 95% CI [-24.88; 6.34]; p 0.26) or parents (B vs. A: 5.49; 95% CI [-8.79; 19.77]; p 0.46). Neither daytime sleepiness nor hypoglycemia fear in children or parents differed significantly between the systems. Neither group met recommended sleep criteria. Conclusion Lack of sleep and fear of hypoglycemia remain a major burden for children with diabetes and their parents. Whilst no significant differences between the systems were found, future technology should consider psychosocial impacts of diabetes and related technologies on children and parents’ lived experience to ensure parity of esteem between physical and mental health outcomes.

    Keywords: Type 1 diabetes (T1D), Children, Parents, Fear of hypoglycemia, Sleep, Sensor augmented pump, iscCGM

    Received: 18 Apr 2024; Accepted: 18 Nov 2024.

    Copyright: © 2024 Schierloh, Aguayo, Fichelle, De Melo Dias, Schritz, Vaillant, Barnard-Kelly, Cohen, Gies and de Beaufort. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ulrike Schierloh, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.