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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1418766

Physical activity affects dysthyreosis by thyroid hormones sensitivity: a population-based study

Provisionally accepted
Shu-yang Zhang Shu-yang Zhang 1*Xue-Qing Hu Xue-Qing Hu 2Cheng Xiang Cheng Xiang 2Tao Xiang Tao Xiang 3Song-Xue Guo Song-Xue Guo 2Fei-Hu Zhi Fei-Hu Zhi 1Ping Zhao Ping Zhao 1Jia-Yan Zhu Jia-Yan Zhu 1Chen-Yang Zhang Chen-Yang Zhang 4
  • 1 Shaoxing Hospital of Traditional Chinese Medicine (Shaoxing TCM Hospital Affiliated to Zhejiang Chinese Medical University), Shaoxing, China
  • 2 The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
  • 3 The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
  • 4 Xiangya School of Medicine, Central South University, Changsha, Hunan Province, China

The final, formatted version of the article will be published soon.

    Objective: Physical activity (PA) plays an important role in human health. However, the relationship between the PA and dysthyreosis was not clear. This study aimed to explore this question. Methods: We performed a population-based study on the basis of the participant's information that was collected from the National Health and Nutrition Examination Survey (NHANES) database. The association of the thyroid hormone and total PA metabolic equivalent task (MET) were assessed via linear regression analysis with adjusting for different covariates. Moreover, we also used path analysis to explore the causality between PA, thyroid hormone index, and dysthyreosis. The restricted cubic spline analysis was used to explore the non-linear relationship between the thyroid hormone index and the PA total MET. Results: A total of 2118 participants agedā‰„20, including 969 females and 1149 males, were collected from NHANES. The linear regression with multivariate adjustment suggested a linear relationship between the PA total MET and Thyroid-Stimulating Hormone Index (TSHI), and Thyroid Feedback Quantile-Based Index (TFQI), respectively. And TFQI and dysthyresis occurrence were significantly correlated (P<0.05). The path analysis showed that the PA total MET affected dysthyreosis occurrence by TFQI. In addition, we found a non-linear relationship between the total PA met and dysthyreosis via restricted cubic spline analysis. Conclusions: PA was significantly correlated with dysthyreosis via thyroid hormone sensitivity. Therefore, it can be considered to prevent the occurrence of dysthyreosis by regulating thyroid hormone sensitivity through PA in daily life.

    Keywords: physical activity, thyroid feedback quantile-based Index, Sensitivity, dysthyreosis, Metabolic Equivalent Task

    Received: 17 Apr 2024; Accepted: 09 Oct 2024.

    Copyright: Ā© 2024 Zhang, Hu, Xiang, Xiang, Guo, Zhi, Zhao, Zhu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Shu-yang Zhang, Shaoxing Hospital of Traditional Chinese Medicine (Shaoxing TCM Hospital Affiliated to Zhejiang Chinese Medical University), Shaoxing, China

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