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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Bone Research
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1418271

The Association between the triglyceride-glucose Index and Bone Turnover Markers in Osteoporotic fractures patients aged 50 and above who are hospitalized for surgical intervention: A Retrospective Cross-Sectional Study

Provisionally accepted
Jian Xv Jian Xv 1,2Shao-han Guo Shao-han Guo 3Min-zhe Xv Min-zhe Xv 3Chong Li Chong Li 3Ya-qin Gong Ya-qin Gong 4Ke Lu Ke Lu 3*
  • 1 Department of Orthopedics, First People's Hospital of Kunshan, Kunshan, China
  • 2 Gusu School, Suzhou, China
  • 3 Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, Jiangsu, China
  • 4 Information Department, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, Jiangsu, China

The final, formatted version of the article will be published soon.

    Objective: To evaluate the correlation between the triglyceride-glucose (TyG) index and bone turnover markers (BTMs) in osteoporotic fractures (OPFs) patients hospitalized for surgical intervention Methods: A retrospective cross-sectional study was conducted on 3558 OPFs patients hospitalized for surgical intervention between January 2017 and July 2022. The study obtained baseline values for various biomarkers and covariates, including fasting blood glucose, β-C-terminal telopeptide of type I collagen (β-CTX), procollagen type 1 N-terminal propeptide (P1NP), triglycerides, age, sex, body mass index, smoking, drinking, low-density lipoprotein, high-density lipoprotein, aspartate aminotransferase, uric acid, the score of American society of anesthesiologists, homocysteine, parathyroid hormone, apolipoprotein B, apolipoprotein A, magnesium, phosphorus and calcium. Multiple linear regression, curve fitting, threshold effects, and subgroup analyses were also applied.After adjusting for covariates in the regression analysis, the results revealed a negative correlation between β-CTX and P1NP levels and the baseline TyG index. Specifically, a one-unit increase in the TyG index was associated with a reduction in β-CTX levels of -0.06 (95% CI: -0.10, -0.01; P-value = 0.012) and a reduction in P1NP levels of -4.70 (95% CI: -9.30, -0.09; P-value = 0.046).Additionally, the inflection points for the nonlinear correlation between the TyG index and β-CTX and P1NP were found to be K = 6.31 and K = 6.63, respectively.The study demonstrated a negative, non-linear relationship among the TyG index, β-CTX and P1NP in OPFs patients hospitalized for surgical intervention. These findings suggest that elevated TyG index levels may adversely affect bone turnover, potentially contributing to the progression of OP.

    Keywords: P1NP, β-CTx, BTMs, Osteoporotic Fractures, TyG index

    Received: 16 Apr 2024; Accepted: 30 Aug 2024.

    Copyright: © 2024 Xv, Guo, Xv, Li, Gong and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ke Lu, Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, Jiangsu, China

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