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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Systems Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1417840

The Relationship Between Dietary inflammatory index and All-Cause and Cardiovascular Disease-Related Mortality in Adults with Metabolic syndrome: A Cohort Study Of NHANES

Provisionally accepted
Qunwei Ma Ma Qunwei Ma Ma 1Ying Zhang Ying Zhang 1Daowen Zhang Daowen Zhang 1Cancan Liu Cancan Liu 1Weiwei Zhu Weiwei Zhu 1Guixia Wang Guixia Wang 1Nannan Xu Nannan Xu 1Xue Zhang Xue Zhang 1Rui Huang Rui Huang 1Huijun Zhang Huijun Zhang 1Shuhang Xu Shuhang Xu 2Chao Liu Chao Liu 2Kuanlu Fan Kuanlu Fan 1*
  • 1 Second Affiliated Hospital, Xuzhou Medical University, Xuzhou, China
  • 2 Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Objective This study aims to investigate the correlation between dietary inflammatory index (DII) and mortality resulting from all-cause and cardiovascular diseases (CVD) in adults affected by metabolic syndrome (MetS).The focus of this study was to analyze the information of 13,751 adults who had been diagnosed with MetS. DII scores were computed based on a 24-hour dietary intake at the start of the study. By implementing both the Cox regression analysis and restricted cubic spline(RCS) analysis, we examined the correlation between DII score and mortality.After a mean follow-up duration of 114 months, a total of 2,343 individuals (representing 13.45% of the sample) died, with 639 fatalities attributed to CVD. The degrees of dietary inflammation were classified into three groups based on DII scores: low, medium, and high-grade. The mortality rates for each tertile of DII were 11.55%, 13.96%, and 15.05%, respectively. In comparison to participants with T1, the multivariate-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for participants with T3 were 1.16 (95% CI: 1.01-1.34) regarding mortality caused by any reason, and 1.26 (95% CI: 0.95-1.68) for mortality related to CVD. Through the use of the Kaplan-Meier survival curve and RCS, it was observed that individuals in the high DII tertile had an increased likelihood of death compared to those in the low DII tertile.Our findings provide validation of the theory that diets high in inflammatory substances contribute to elevated mortality rates for all causes and CVDrelated deaths in individuals diagnosed with MetS.

    Keywords: All-cause mortality, Cardiovascular disease-related mortality, metabolic syndrome, Dietary inflammation index, National Health and Nutrition Examination Survey

    Received: 15 Apr 2024; Accepted: 20 Dec 2024.

    Copyright: © 2024 Ma, Zhang, Zhang, Liu, Zhu, Wang, Xu, Zhang, Huang, Zhang, Xu, Liu and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kuanlu Fan, Second Affiliated Hospital, Xuzhou Medical University, Xuzhou, China

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