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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1417528
This article is part of the Research Topic Advances in precision medicine in the management of thyroid nodules and thyroid cancer View all 23 articles

Construction of a new tool for predicting cancer-specific survival in papillary thyroid cancer patients who have not received surgery

Provisionally accepted
Sanjun Chen Sanjun Chen 1Yanmei Tan Yanmei Tan 2Xinping Huang Xinping Huang 2Yanfei Tan Yanfei Tan 1*
  • 1 The First People's Hospital of Chenzhou, Chenzhou, China
  • 2 Xiangnan University, Chenzhou, Hunan Province, China

The final, formatted version of the article will be published soon.

    The prevalence of papillary thyroid cancer is gradually increasing and the trend of youthfulness is obvious. Some patients may not be able to undergo surgery, which is the mainstay of treatment, due to physical or financial reasons.Therefore, the prediction of cancer-specific survival (CSS) in patients with non-operated papillary thyroid cancer is necessary.: Patients' demographic and clinical information was extracted from the Surveillance, Epidemiology, and End Results database. SPSS software was used to perform Cox regression analyses as well as propensity score matching analyses. R software was used to construct and validate the nomogram. X-tile software was used to select the best cutoff point for patient risk stratification. Results: A total of 1319 patients were included in this retrospective study. After Cox regression analysis, age, grade, T stage, M stage, radiotherapy, and chemotherapy were used to construct the nomogram. C-index, calibration curves, and receiver operating characteristic curves all verified the high predictive accuracy of the nomogram. The decision curve analysis demonstrated that patients could gain clinical benefit from this predictive model. Survival curve analysis after propensity score matching demonstrated the positive effects of radiotherapy on CSS in non-operated patients. Conclusion: Our retrospective study successfully established a nomogram that accurately predicts CSS in patients with non-operated papillary thyroid cancer and demonstrated that radiotherapy for operated patients can still help improve prognosis.These findings can help clinicians make better choices.

    Keywords: Papillary thyroid cancer, non-operative, PSM, nomogram, SEER

    Received: 15 Apr 2024; Accepted: 16 Jul 2024.

    Copyright: © 2024 Chen, Tan, Huang and Tan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yanfei Tan, The First People's Hospital of Chenzhou, Chenzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.