Skip to main content

ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1417485
This article is part of the Research Topic Clinical Implications of Obesity and Lipid-Related Parameters on Cardiometabolic Diseases - Volume II View all 11 articles

The serum uric acid-to-high-density lipoprotein cholesterol ratio is a predictor for all-cause and cardiovascular disease mortality: a cross-sectional study

Provisionally accepted
Zhanbin Li Zhanbin Li 1,2,3,4,5,6Qiaoran Liu Qiaoran Liu 7Zhenyu Yao Zhenyu Yao 2,4,5,6,8,9*
  • 1 Department of Endocrinology, Shandong Provincial Hospital, Shandong University; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Jinan, China
  • 2 Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, 250021, China
  • 3 Shandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China
  • 4 “Chuangxin China” Innovation Base of stem cell and Gene Therapy for endocrine Metabolic diseases, Jinan, China
  • 5 Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, Shandong, Jinan, China
  • 6 Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, China
  • 7 Department of breast surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, 250021, China
  • 8 Department of Endocrinology, Shandong Provincial Hospital, Shandong University; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Jinan, Shandong, 250021, China
  • 9 Institute of Endocrine and Metabolic Diseases, Shandong University, Jinan, China

The final, formatted version of the article will be published soon.

    Objective: The exact relationship between the serum uric acid-to-HDL cholesterol ratio (UHR) and mortality rates remains enigmatic among American adults. This study aims to clarify the association between UHR and both all-cause and cardiovascular disease (CVD) mortality in US adults.Methods: This study enrolled 48054 patients from the National Health and Nutrition Examination Survey (NHANES). Mortality outcomes were determined by linking to National Death Index (NDI) records up to December 31,2019. Multivariate Cox proportional hazards models were constructed to analyze explore the associations between UHR and mortality. Dose-response relationships were explored using restricted cubic splines, and stratified analyses were conducted based on gender, age, race, education, PIR, smoking status, alcohol intake, physical activity, BMI, diabetes and hypertension.Results: During the follow-up period, the overall mortality for all-cause and CVD malignant neoplasms was 10.9% and 2.7%, respectively. The adjusted HRs in the highest quintile were 1.16 (95% CI: 1.05, 1.29) for all-cause mortality and 1.2 (95% CI: 1, 1.45) for CVD mortality. In diabetes, obese, and CVD subgroups, significantly elevated adjusted HRs were observed for both all-cause and CVD mortality. Specifically, diabetes patients had adjusted

    Keywords: The serum uric acid-to-high-density lipoprotein cholesterol ratio, Mortality, cardiovascular disease, obese, diabetes, NHANES

    Received: 15 Apr 2024; Accepted: 28 Aug 2024.

    Copyright: © 2024 Li, Liu and Yao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhenyu Yao, Department of Endocrinology, Shandong Provincial Hospital, Shandong University; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Jinan, Shandong, 250021, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.