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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 15 - 2024 |
doi: 10.3389/fendo.2024.1417009
This article is part of the Research Topic Advances in precision medicine in the management of thyroid nodules and thyroid cancer View all 23 articles
Causal association between gut microbiota and thyroid nodules: a bidirectional two-sample Mendelian randomization study
Provisionally accepted
Shaoshuai Yan
1,2
He Jiawei
3
Xudong Yu
1,2*
Jianwei Shang
1,2*
Yaosheng Zhang
1,2*
Han Bai
1,2
Xingyu Zhu
1,2*
Xiaoming Xie
1,2
Leanne Lee
2*- 1 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, Beijing Municipality, China
- 2 Beijing University of Chinese Medicine, Beijing, Beijing Municipality, China
- 3 Hubei University of Chinese Medicine, Wuhan, Hubei Province, China
Objective: Emerging evidence suggests alterations in gut microbiota (GM) composition following thyroid nodules (TNs) development, yet the causal relationship remains unclear. Utilizing Mendelian Randomization (MR), this study aims to elucidate the causal dynamics between GM and TNs.Methods: Employing summary statistics from the MiBioGen consortium (n=18,340) and FinnGen consortium (1,634 TNs cases, 263,704 controls), we conducted univariable and multivariable MR analyses to explore the GM-TNs association. Techniques including inverse variance weighted, MR-Egger regression, weighted median, and MR-PRESSO were utilized for causal inference.Instrumental variable heterogeneity was assessed through Cochran's Q statistic and leave-one-out analysis. Reverse MR was applied for taxa showing significant forward MR associations, with multivariate adjustments for confounders.
Keywords: gut microbiota,thyroid nodules,Mendelian randomization,causal association,Thyroid-Gut Axis Results: Our findings suggest that certain microbiota, identified as Ruminococcaceae_NK4A214_group (OR, 1.89, 95%CI, 0.47-7.64, p = 0.040), Senegalimassilia (OR, 1.72, 95%CI, 1.03-2.87, p =0.037), Lachnospiraceae (OR,0.64, 95%CI,0.41-0.99, p =0.045), exhibit a protective influence against TNs' development, indicated by negative causal associations. In contrast, microbiota categorized as Desulfovibrionales (OR, 0.63, 95%CI, 0.41-0.95
Received: 13 Apr 2024; Accepted: 10 Jul 2024.
Copyright: © 2024 Yan, Jiawei, Yu, Shang, Zhang, Bai, Zhu, Xie and Lee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xudong Yu, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100001, Beijing Municipality, China
Jianwei Shang, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100001, Beijing Municipality, China
Yaosheng Zhang, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100001, Beijing Municipality, China
Xingyu Zhu, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100001, Beijing Municipality, China
Leanne Lee, Beijing University of Chinese Medicine, Beijing, 100029, Beijing Municipality, China
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