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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1416634
This article is part of the Research Topic Exploring the New Biomarkers and Clinical Indicators for Diabetes: Insights from Real-World Studies View all 18 articles

Nonlinear relationship between triglyceride-glucose index and the risk of prediabetes and diabetes: a secondary retrospective cohort study

Provisionally accepted
Changchun Cao Changchun Cao 1*Haofei Hu Haofei Hu 2Peng Xiao Peng Xiao 1Yibang Zan Yibang Zan 1Xinru Chang Xinru Chang 1Yong Han Yong Han 2*Xiaohua Zhang Xiaohua Zhang 1Yulong Wang Yulong Wang 2
  • 1 Department of Rehabilitation Medicine, Dapeng New District Nan’ao People’s Hospital, Shenzhen, China
  • 2 Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China

The final, formatted version of the article will be published soon.

    The triglyceride-glucose (TyG) index, recognized for its cost-efficiency and simplicity, serves as an accessible indicator of insulin resistance. Yet, its correlation with the risk of prediabetes and diabetes (Pre-DM/DM) in the Chinese demographic remains uncertain.Consequently, our study explored the association between the TyG index and the development of Pre-DM/DM within the Chinese population.The retrospective cohort study was carried out utilizing data from a health screening initiative. The study included 179541 adults over 20 who underwent medical examinations at the Rich Healthcare Group over a period spanning from 2010 to 2016. The correlation between the TyG index and Pre-DM/DM risk was investigated using Cox regression analysis. Furthermore, Cox proportional hazards regression with cubic spline functions and smooth curve fitting was incorporated to explore their non-linear connection.The mean age of study participants was 41.18 ± 12.20 years old, and 95255 (53.05%) were male. During a median follow-up of 3.01 years, 21281 (11.85%) participants were diagnosed with Pre-DM/DM. After adjusting the potential confounding factors, the results showed that the TyG index was positively correlated with incident Pre-DM/DM (HR: 1.67, 95%CI: 1.62-1.71, P< 0.001).Additionally, a non-linear association was observed between the TyG index and the onset of Pre-DM/DM, with an inflection point identified at 8.73. Hazard ratios (HR) to the left and right of this inflection point were 1.95 (95%CI: 1.86-2.04) and 1.34 (95%CI: 1.27-1.42), respectively. Furthermore, sensitivity analyses confirmed the stability of these findings.The TyG index exhibited a non-linear positive relationship with the risk of Pre-DM/DM. These findings imply that maintaining the TyG index at a lower, specified threshold may be beneficial in mitigating the onset of Pre-DM/DM.

    Keywords: Triglyceride-glucose index, triglyceride, Fasting plasma glucose, prediabetes, Diabetes, Non-linearity

    Received: 12 Apr 2024; Accepted: 05 Sep 2024.

    Copyright: © 2024 Cao, Hu, Xiao, Zan, Chang, Han, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Changchun Cao, Department of Rehabilitation Medicine, Dapeng New District Nan’ao People’s Hospital, Shenzhen, China
    Yong Han, Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China

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