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REVIEW article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1416611
This article is part of the Research Topic Deepening the Relationship between Diabetes, Oral Health and Periodontal Disease View all 7 articles

Microbiomic Insights into the Oral Microbiome's Role in Type 2 Diabetes Mellitus: Standardizing Approaches for Future Advancements

Provisionally accepted
Huifang Guan Huifang Guan 1Shuang Zhao Shuang Zhao 1Yuanfei Tan Yuanfei Tan 2Yuxin Zhang Yuxin Zhang 3Yanjiao Zhang Yanjiao Zhang 3Fang Xinyi Fang Xinyi 3,4Runyu Miao Runyu Miao 3,4Ruiyang Yin Ruiyang Yin 3Yiyi Yao Yiyi Yao 3Yang Cao Yang Cao 2Jiaxing Tian Jiaxing Tian 3*
  • 1 Changchun University of Chinese Medicine, Changchun, China
  • 2 The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin Province, China
  • 3 Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China
  • 4 Beijing University of Chinese Medicine, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    The burgeoning field of microbiomics has unveiled significant insights into the role of the oral microbiome in the pathophysiology of Type 2 Diabetes Mellitus (T2DM), with this review focusing on recent advancements in diabetic oral microbiology, its clinical applications, and identifying factors that may affect study interpretations. A comprehensive review across various databases, including PubMed and Google Scholar, was conducted to collate original research data published in the past five years, specifically targeting studies exploring the impact of the oral microbiome on T2DM and emphasizing research that employs microbiomic approaches in clinical patient populations. The findings delineate the intricate interplay between T2DM and oral microbiome dysbiosis, highlighting significant microbial shifts following periodontal and antidiabetic treatments, and pointing to the complexity of the relationship between oral health and systemic disease. The observed oral microbial shifts in T2DM underscore the critical need for standardized research methodologies in microbiomic studies, suggesting that by adopting a unified approach, future research can more effectively elucidate the oral microbiome's role in T2DM. This could pave the way for innovative diagnostic and therapeutic strategies in managing T2DM and its oral health complications, thus making a pertinent overview of the work within the field.

    Keywords: Diabetes Mellitus, oral microbiome, Periodontitis, diabetic oral microbiology, Microbial Diversity

    Received: 12 Apr 2024; Accepted: 06 Nov 2024.

    Copyright: © 2024 Guan, Zhao, Tan, Zhang, Zhang, Xinyi, Miao, Yin, Yao, Cao and Tian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiaxing Tian, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, Beijing Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.