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REVIEW article

Front. Endocrinol.
Sec. Pituitary Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1414223

scRNA sequencing technology for PitNET studies

Provisionally accepted
Marina Utkina Marina Utkina *Walaa Asaad Walaa Asaad Anastasia Shcherbakova Anastasia Shcherbakova Sergey Popov Sergey Popov Galina Melnichenko Galina Melnichenko Natalia Mokrysheva Natalia Mokrysheva
  • Endocrinology Research Center, Moscow, Russia

The final, formatted version of the article will be published soon.

    Pituitary neuroendocrine tumors (PitNETs) are common, most likely benign tumors with complex clinical characteristics related to hormone hypersecretion and/or growing sellar tumor mass. PitNET types are classified according to their expression of specific transcriptional factors (TFs) and hormone secretion levels. Some types show aggressive, invasive, and reoccurrence behavior. Current research is being conducted to understand the molecular mechanisms regulating these high-heterogeneous neoplasms originating from adenohypophysis, and single-cell RNA sequencing (scRNA-seq) technology is now playing an essential role in these studies due to its remarkable resolution at the single-cell level. This review describes recent studies on human PitNETs performed with scRNA-seq technology, highlighting the potential of this approach in revealing these tumor pathologies, behavior, and regulatory mechanisms.

    Keywords: PitNETs, ScRNA-seq, Pituitary tissue, pituitary development, PitNETs structure, PitNETs invasion, PitNETs immunity, Tumor Microenvironment

    Received: 08 Apr 2024; Accepted: 10 Jul 2024.

    Copyright: © 2024 Utkina, Asaad, Shcherbakova, Popov, Melnichenko and Mokrysheva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Marina Utkina, Endocrinology Research Center, Moscow, Russia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.