AUTHOR=Magnuson Mark A. , Osipovich Anna B. 

TITLE=Ca2+ signaling and metabolic stress-induced pancreatic β-cell failure

JOURNAL=Frontiers in Endocrinology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1412411

DOI=10.3389/fendo.2024.1412411

ISSN=1664-2392

ABSTRACT=<p>Early in the development of Type 2 diabetes (T2D), metabolic stress brought on by insulin resistance and nutrient overload causes β-cell hyperstimulation. Herein we summarize recent studies that have explored the premise that an increase in the intracellular Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>), brought on by persistent metabolic stimulation of β-cells, causes β-cell dysfunction and failure by adversely affecting β-cell function, structure, and identity. This mini-review builds on several recent reviews that also describe how excess [Ca<sup>2+</sup>]<sub>i</sub> impairs β-cell function.</p>