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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1412373
This article is part of the Research Topic Exploring the New Biomarkers and Clinical Indicators for Diabetes: Insights from Real-World Studies View all 27 articles

Relationship between Ferroptosis and Healing of Diabetic Foot Ulcer: A Prospective Clinical Study

Provisionally accepted
Qian Jiang Qian Jiang 1*Long Tang Long Tang 2*Shu ao Xiao Shu ao Xiao 2*
  • 1 Department of Geriatrics, Second Provincial People’s Hospital of Gansu, Lanzhou, China
  • 2 Department of Burn and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University, Xian, China

The final, formatted version of the article will be published soon.

    Objective Diabetic foot ulcer (DFU) is one of the common complications in patients with diabetes mellitus (DM). In order to find a method to monitor and treat the refractory DFU, the ferroptosis level in DFU and traumatic wounds (TW) was monitored and the difference between them was analyzed. At the same time, this study further analyzed the correlation of ferroptosis levels with DM severity and DFU's healing. Methods A prospective cohort study was from January, 2021 to December, 2023 in the Second People's Hospital of Gansu province, which included 59 patients with DFU and 42 patients with TW. We then used the kit to detect the indicators related to ferroptosis, including 4-Hydroxynonenal (4-HNE), Malondialdehyde (MDA) and reactive oxygen species (ROS) , in the wound exudate of the two groups of patients.The DFU group had higher ferroptosis level than the TW group ( 4-HNE: P = 0.003, MDA: P＜0.001, ROS: P＜0.001). The severity of diabetes was significantly associated with ferroptosis level in DFU patients(r = 0.936, P ＜0.001) . The results of multiple regression analysis showed that 4-HNE (β = -0.182, P = 0.008) , MDA (β = -0.478, P ＜0.001) and ROS (β = -0.394, P＜0.001) significantly negatively predicted the healing rate of DFU. Conclusion As a new monitoring and therapeutic target, ferroptosis level plays an important role in predicting the healing rate of DFU and assisting clinical treatment decision-making.

    Keywords: ferroptosis, Diabetic foot ulcer, Wound Healing, Wound monitoring, Chronic wound healing

    Received: 04 Apr 2024; Accepted: 20 Dec 2024.

    Copyright: © 2024 Jiang, Tang and Xiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qian Jiang, Department of Geriatrics, Second Provincial People’s Hospital of Gansu, Lanzhou, China
    Long Tang, Department of Burn and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University, Xian, China
    Shu ao Xiao, Department of Burn and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University, Xian, China

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