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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Endocrinology of Aging
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1412160
This article is part of the Research Topic Diagnostic, prognostic and treatment efficacy power of biomarkers of aging for frailty, age-related diseases and multimorbidity View all 14 articles

DNA polymorphisms in inflammatory and endocrine signals linked to frailty are also associated with obesity: data from the FRASNET cohort

Provisionally accepted
Sarah Damanti Sarah Damanti 1*Lorena Citterio Lorena Citterio 2Laura Zagato Laura Zagato 3Elena Brioni Elena Brioni 3Cristiano Rn Cristiano Rn 3Marco Rn Marco Rn 3Rebecca De Lorenzo Rebecca De Lorenzo 1Maria P. Ruggiero Maria P. Ruggiero 1Simona Santoro Simona Santoro 1Eleonora Senini Eleonora Senini 1Marco Messina Marco Messina 1Giordano Vitali Giordano Vitali 3Paolo Manunta Paolo Manunta 1Angelo A. Manfredi Angelo A. Manfredi 1Chiara Lanzani Chiara Lanzani 1Patrizia Rovere Querini Patrizia Rovere Querini 1
  • 1 Vita-Salute San Raffaele University, Milan, Italy
  • 2 San Raffaele Scientific Institute (IRCCS), Milan, Lombardy, Italy
  • 3 San Raffaele Hospital (IRCCS), Milan, Lombardy, Italy

The final, formatted version of the article will be published soon.

    Background: Obesity and frailty are prevalent geriatric conditions that share some pathophysiological mechanisms and are associated with adverse clinical outcomes. The relationship between frailty, obesity, and polymorphism remains inadequately explored. Single nucleotide polymorphisms (SNPs) offer insights into genetic predispositions that may influence the development of both frailty and obesity.We aimed at investigating whether single nucleotide polymorphisms (SNPs) associated with frailty also play a role in obesity. Data were collected from the FRASNET cross-sectional study, which included community-dwelling older individuals residing in Milan and nearby areas. Participants were recruited through random sampling. They underwent multidimensional geriatric assessments, which included the collection of blood samples for single nucleotide polymorphism (SNP) analysis. Frailty was assessed using the frailty index, and body composition was evaluated using bioelectrical impedance analysis and anthropometric measures.Results: SNPs related to frailty and linked to the renin-angiotensin system (CYP11B2 rs1799998, AGT rs5051, AGTR1 rs2131127), apoptosis pathways (CASP8 rs6747918), growth hormone signaling (GHR rs6180), inflammation (TLR4 rs5030717, CD33 rs3865444, FN1 rs7567647), adducin (ADD3 rs3731566), and the 9p21-23 region (rs518054) were found to be associated with various measures of obesity in community-dwelling older adults.Frailty-related SNPs contribute to obesity in community-dwelling older adults. We identified a novel association between adducin SNPs and visceral fat, which has not been previously reported. Detecting genetic predispositions to obesity and frailty early could aid in identifying individuals at risk, facilitating the adoption of preventive interventions. This represents an initial step toward promoting early intervention strategies.

    Keywords: Obesity, Frailty, SNP, predisposition, Link

    Received: 04 Apr 2024; Accepted: 28 Jun 2024.

    Copyright: © 2024 Damanti, Citterio, Zagato, Brioni, Rn, Rn, De Lorenzo, Ruggiero, Santoro, Senini, Messina, Vitali, Manunta, Manfredi, Lanzani and Rovere Querini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Sarah Damanti, Vita-Salute San Raffaele University, Milan, Italy

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