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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1411803
This article is part of the Research Topic Vascular Dysfunction and Endocrine Disorders View all 3 articles

Association between serum estradiol levels and abdominal aortic calcification in postmenopausal woman: a cross-sectional study

Provisionally accepted
Lan He Lan He 1Xu Li Xu Li 1E Shen E Shen 2*Yong-Ming He Yong-Ming He 1*
  • 1 The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
  • 2 Department of Ultrasound, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China

The final, formatted version of the article will be published soon.

    The association between Estradiol (E2) levels and abdominal aortic calcification (AAC) in postmenopausal women remains unclear.Methods 614 postmenopausal women from the 2013-2014 NHANES survey cycle were included in this study. The study population was divided into 3 groups according to E2 tertiles: Tertile1 (2.12-3.57pg/mL), Tertile2 (3.60-7.04pg/mL), and Tertile3 (7.06-38.4pg/mL). Estrogen concentration data were natural logarithmically transformed. A Kauppila score > 5 was regarded as prominent arterial calcification and was used to define (EAAC). Logistic regression models were used to assess the association between E2 levels and EAAC prevalence. Subgroup analyses were performed to test whether the association between E2 levels and EAAC prevalence was consistent in different groups.Sensitivity analyses tested the stability of the model in women older than 45 years.Results EAAC prevalence was significantly higher in Tertile1 (16.6%) than in Tertile2 (9.8%) and Tertile3 (8.3%). On a continuous scale, the adjusted model showed a 58% [OR (95%CI), 1.58 (1.02, 2.54)] increase in the risk of EAAC prevalence for per unit decrease in ln(E2) . On a categorical scale, the adjusted model showed that Tertile1 and Tertile2 were 2.55 [OR (95%CI), 2.55 (1.10, 5.92)] and 1.31[OR (95%CI), 1.31(1.03, 2.57)] times higher risk of suffering from EAAC than Tertile3, respectively.This study found that a higher prevalence of AAC in postmenopausal women is closely associated with lower serum E2 levels. Our research further underscores the importance of E2 in maintaining cardiovascular health in postmenopausal women and suggests that monitoring E2 levels may aid in the early prevention and management of AAC and related cardiovascular diseases.

    Keywords: ABDOMINAL AORTIC CALCIFICATION, Estradiol, NHANES, Postmenopausal woman, Cross-sectional study

    Received: 03 Apr 2024; Accepted: 03 Sep 2024.

    Copyright: © 2024 He, Li, Shen and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    E Shen, Department of Ultrasound, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, 200030, China
    Yong-Ming He, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu Province, China

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