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REVIEW article

Front. Endocrinol.
Sec. Translational and Clinical Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1409000
This article is part of the Research Topic Exosome-Based Advances in Endocrine and Metabolic Diseases: From Diagnosis to Therapy View all 6 articles

Roles of Extracellular Vesicles Derived from Healthy and Obese Adipose Tissue in Inter-Organ Crosstalk and Potential Clinical Implication

Provisionally accepted
YUE HAN YUE HAN 1Bowen Liu Bowen Liu 2*
  • 1 Beihang University, Beijing, China
  • 2 The Chinese University of Hong Kong, Shenzhen, Shenzhen, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Extracellular vesicles (EV) are nanovesicles containing bioactive molecules including proteins, nucleic acids and lipids that mediate intercellular and inter-organ communications, holding promise as potential therapeutics for multiple diseases. Adipose tissue (AT) serves as a dynamically distributed energy storage organ throughout the body, whose accumulation lead to obesity, a condition characterized by infiltration with abundant immune cells. Emerging evidence has illustrated that EVs secreted by AT are the novel class of adipokines that regulate the homeostasis between AT and peripheral organs. However, most of the studies focused on the investigations of EVs derived from adipocytes or adipose-derived stem cells (ADSC), the summarization of functions in cellular and inter-organ crosstalk of EVs directly derived from adipose tissue (AT-EV) are still limited. Here, we provide a systemic summary on the key components and functions of EVs derived from healthy adipose tissue, showing their significance on the tissue recovery and metabolic homeostasis regulation. Also, we discuss the harmful influences of EVs derived from obese adipose tissue on the distal organs. Furthermore, we elucidate the potential applications and constraints of EV from healthy patients lipoaspirates as therapeutic agents, highlighting the potential of AT-EVs as a valuable biological material with broad prospects for future clinical use.

    Keywords: extracellular vesicles, Adipose Tissue, Obesity, Clinical implication, inter-organ communication

    Received: 29 Mar 2024; Accepted: 12 Aug 2024.

    Copyright: © 2024 HAN and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Bowen Liu, The Chinese University of Hong Kong, Shenzhen, Shenzhen, Guangdong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.