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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1407859

A new LNC89 /LNC60-Col11a2 axis revealed by whole-transcriptome analysis may be associated with goiters related to excess iodine nutrition

Provisionally accepted
Guanying Nie Guanying Nie 1Ming Li Ming Li 2Wei Zhang Wei Zhang 1Shuang Li Shuang Li 3Fanggang Meng Fanggang Meng 1Jiahui Li Jiahui Li 1Dianjun Sun Dianjun Sun 1*
  • 1 Harbin Medical University, Harbin, Heilongjiang, China
  • 2 Other
  • 3 The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China

The final, formatted version of the article will be published soon.

    Goiter related to excessive iodine nutrition remains a significant public health issue in some countries. There has been no reported study on long noncoding RNAs (lncRNAs) related to goiters. In this study, goiter was induced by drinking water with excess iodine for 10 or 20 weeks in Kunming mice. Whole transcriptome sequencing results showed that LNC89 expression increased in mice goiter tissues compared to normal thyroid tissues and higher in 20 weeks goiter tissues than in 10 weeks goiter tissues, which were identified by qRT-PCR. Cooperate with human-mouse homologous gene conversion, a new LNC89 /LNC60-Col11a2 axis was predicted by LncTar and expression correlation analysis based on whole transcriptome sequencing results. Increased Col11a2 expression was also identified by qRT-PCR and Western blot in the mice goiter tissues. In the human normal thyroid cell line Nthy-ori-3 treated with KI03, LNC60 and Col11a2 expression increased with promoted cell viability, which were

    Keywords: Iodine excess, thyroid, Goiter, Col11a2, lncRNA

    Received: 04 Apr 2024; Accepted: 11 Oct 2024.

    Copyright: © 2024 Nie, Li, Zhang, Li, Meng, Li and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dianjun Sun, Harbin Medical University, Harbin, 130012, Heilongjiang, China

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