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MINI REVIEW article

Front. Endocrinol.
Sec. Cellular Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1406455
This article is part of the Research Topic Endocrine Imbalances of Mineral Ions and Vitamins in Chronic Disease Pathogenesis View all 3 articles

Neuroprotective Effects of Magnesium: Implications for Neuroinflammation and Cognitive Decline

Provisionally accepted
Mohammed S. Razzaque Mohammed S. Razzaque 1*Veer Patel Veer Patel 2William B. Grant William B. Grant 3Carolyn Dean Carolyn Dean 4
  • 1 Lake Erie College of Osteopathic Medicine, Erie, United States
  • 2 LECOM Health, Erie, Pennsylvania, United States
  • 3 Sunlight Nutrition and Health Research Center, San Francisco, California, United States
  • 4 New Capstone, Inc., Mooresville, United States

The final, formatted version of the article will be published soon.

    Neurodegenerative diseases, which are characterized by progressive neuronal loss and cognitive decline, are a significant concern for the aging population. Neuroinflammation, a shared characteristic of these diseases, is implicated in their pathogenesis. This article briefly summarizes the role of magnesium, an essential mineral involved in numerous enzymatic reactions and critical for neuronal bioactivity, in the context of neuroinflammation and cognitive decline. The potential neuroprotective effects of magnesium, including the mechanisms of neuroprotection by magnesium through maintaining neuronal ion homeostasis, mitigating inflammation, and preventing excitotoxicity, are also described. Additionally, we discuss the impact of inadequate magnesium on neuroinflammation and its potential as a therapeutic agent for attenuating cognitive decline to improve neurodegenerative conditions.

    Keywords: Magnesium, Neuroinflammation, neurodegenerative disease, Cognition, cognitive decline, Neuroprotection

    Received: 25 Mar 2024; Accepted: 28 Aug 2024.

    Copyright: © 2024 Razzaque, Patel, Grant and Dean. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Mohammed S. Razzaque, Lake Erie College of Osteopathic Medicine, Erie, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.