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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 15 - 2024 |
doi: 10.3389/fendo.2024.1405758
The Association Between Circulating Saturated Fatty Acids and Thyroid Function: Results from the NHANES 2011-2012
Provisionally accepted- 1 Department of Endocrinology and Metabolism, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning, China
- 2 Department of Clinical Nutrition and Metabolism, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China, Dalian, Liaoning Province, China
- 3 Department of General Surgery, The Sixth People's Hospital of Shenyang, Shenyang, Liaoning Province, China
Methods: To explore potential associations, we conducted an investigation with 579 participants from the National Health and Nutrition Examination Survey (NHANES) 2011-2012. Subgroup analyses and multivariable linear regression models were used to estimate the relationships between eleven distinct SFA concentrations and various thyroid parameters.Results: For 579 adults, subgroup analysis of TSH revealed significant differences in nine specific SFAs and the total SFA levels (all p < 0.05). Furthermore, multivariable linear regression analysis identified positive correlations between certain SFAs and various parameters, including thyroid stimulating hormone (TSH), total triiodothyronine (TT3), free triiodothyronine (FT3), thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb), thyroglobulin (Tg), the ratio of FT3 to free thyroxine (FT4) (FT3/FT4), and the thyrotroph T4 resistance index (TT4RI). Conversely, negative correlations were observed between certain SFAs and total thyroxine (TT4), FT4, the ratio of FT3/TT3, and the thyroid feedback quantile-based index (TFQI) (all p < 0.05).These findings collectively suggest associations between SFAs and thyroid parameters, highlighting the need for future studies to elucidate the underlying mechanisms of these interactions.
Keywords: saturated fatty acids, Thyroid function, Thyroid Hormones, Lipid Metabolism, National Health and Nutrition Examination Survey
Received: 23 Mar 2024; Accepted: 10 Sep 2024.
Copyright: © 2024 Zhao, 昕楠, Liu, Li, Li, Gao, Han and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shen Li, Department of Endocrinology and Metabolism, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning, China
Xinyu Li, Department of Endocrinology and Metabolism, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning, China
Zhengnan Gao, Department of Endocrinology and Metabolism, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning, China
Cheng Han, Department of Clinical Nutrition and Metabolism, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China, Dalian, Liaoning Province, China
Zizhao Zhu, Department of General Surgery, The Sixth People's Hospital of Shenyang, Shenyang, Liaoning Province, China
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