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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1405550

Perinatal Complications and Neonatal Outcomes in In Vitro Fertilization/Intracytoplasmic Sperm Injection: A Propensity Score Matching Cohort Study

Provisionally accepted
Ying Chen Ying Chen 1Zhang Mengjie Zhang Mengjie 2Gao Yumei Gao Yumei 1Li Mingming Li Mingming 3Zheng Wenjun Zheng Wenjun 1Guo Xueyan Guo Xueyan 1Fei Li Fei Li 1*
  • 1 First People's Hospital of Shangqiu, Shangqiu, Henan Province, China
  • 2 First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Region, China
  • 3 Zhengzhou University, Zhengzhou, Henan Province, China

The final, formatted version of the article will be published soon.

    Background: The utilization of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) has witnessed a significant increase in recent years. However, the comparative perinatal and neonatal outcomes compared to natural pregnancies are unclear. This study aims to compare the outcomes of pregnancies from IVF and ICSI with natural pregnancies. Methods: This retrospective, propensity score-matched cohort study was conducted at the First People's Hospital of Shangqiu and The First Affiliated Hospital of Xinjiang Medical University, involving 5,628 patients from February 2019 to December 2022. It compared pregnancies achieved through IVF/ICSI with those conceived naturally. The primary outcomes assessed were perinatal complications and neonatal health parameters. Propensity score matching and multivariate logistic regression analysis were employed to adjust for potential confounders and identify independent associations. Results: After propensity score matching, the IVF/ICSI group demonstrated significantly higher rates of placental adherence (12.1% vs. 7.4%, p < 0.001) and postpartum hemorrhage (11.1% vs. 7.6%, p = 0.002) compared to the NP group. Neonates in the IVF/ICSI group had a lower gestational age (38.21 ± 2.12 weeks vs. 38.63 ± 2.29 weeks, p < 0.001), reduced birth weight (3159.42 ± 722.75 g vs. 3211.31 ± 624.42 g, p = 0.032), and an increased preterm delivery rate (11.2% vs. 8.9%, p = 0.017). Multivariate analysis further confirmed these findings, highlighting the independent associations between IVF/ICSI and these adverse outcomes. Conclusion: This study suggests a potential correlation between the use of IVF/ICSI and unfavorable perinatal and neonatal outcomes. These findings underscore the critical need for ongoing monitoring and research efforts to enhance the safety and effectiveness of these reproductive technologies.

    Keywords: This retrospective, propensity score-matched cohort study was conducted at the First In vitro fertilization/Intracytoplasmic sperm injection, Natural pregnancies, Perinatal complications, Neonatal outcomes, Propensity score matching

    Received: 23 Mar 2024; Accepted: 04 Jul 2024.

    Copyright: © 2024 Chen, Mengjie, Yumei, Mingming, Wenjun, Xueyan and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Fei Li, First People's Hospital of Shangqiu, Shangqiu, 476100, Henan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.