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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1402575
This article is part of the Research Topic Infertility and Endometriosis View all 19 articles

The use of propensity score matching to assess the effectiveness of the endometrial receptivity analysis in patients with recurrent implantation failure

Provisionally accepted
Shuang Yu Shuang Yu 1Yongjie Zhang Yongjie Zhang 1Na Li Na Li 2Zhuolun Su Zhuolun Su 1Wenjing Li Wenjing Li 1Hua Lou Hua Lou 1*Yichun Guan Yichun Guan 1*
  • 1 Reproductive Center, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China
  • 2 Reproductive Center, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China

The final, formatted version of the article will be published soon.

    Background: One potential cause of implantation failure is abnormal endometrial receptivity, and how to objectively evaluate endometrial receptivity has been a matter of great concern. Endometrial receptivity analysis (ERA), a next-generation sequencing-based test that assesses endometrial gene expression, may be valuable in predicting endometrial receptivity, but whether ERA improves pregnancy outcomes in patients with recurrent implantation failure (RIF) is currently controversial.The purpose of this study was to investigate the effect of ERA on pregnancy outcomes in patients with RIF.We performed a retrospective cohort study analysis for a population of patients with RIF undergoing frozen embryo transfer (FET) cycles in the reproductive center of the Third Affiliated Hospital of Zhengzhou University from January 2019 to December 2022(n=1598). FET cycles with personalized embryo transfer (PET) under ERA guidance were included in the ERA group (n=43); after using propensity score matching (PSM), a total of 120 FET cycles were included as a control group. Pregnancy outcomes were compared between the two groups. Further, the relationship between the number of previous implant failures and the rate of implant window displacement was discussed. The factors affecting the window of implantation (WOI) displacement were also assessed.Results: There was no statistically significant difference in embryo implantation rate, clinical pregnancy rate, spontaneous abortion rate, and live birth rate between the ERA group and the matched control patients (P > 0.05). There was no significant difference in the rate of WOI displacement between patients in the moderate or severe groups (P > 0.05) and no significant difference in pregnancy outcome ( P>0.05). Finally, analysis of the clinical data of patients in the receptive and non-receptive groups did not uncover any factors influencing WOI displacement. The results of the study showed no significant difference in pregnancy outcomes in patients who received ERA compared to those who did not.

    Keywords: endometrial receptivity analysis, Frozen embryo transfer, in vitro fertilization, Propensity score matching, recurrent implantation failure, Personalized embryo transfer

    Received: 17 Mar 2024; Accepted: 19 Dec 2024.

    Copyright: © 2024 Yu, Zhang, Li, Su, Li, Lou and Guan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Hua Lou, Reproductive Center, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China
    Yichun Guan, Reproductive Center, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China

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