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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Endocrinology of Aging
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1402551
This article is part of the Research Topic Hormones and Aging related diseases View all articles

The relationship between inflammatory bowel disease and sarcopenia-related traits: a bidirectional two-sample mendelian randomization study

Provisionally accepted
Zhihuang Sun Zhihuang Sun *Guangwei Liu Guangwei Liu *Jiajia Xu Jiajia Xu *Xianyu Zhang Xianyu Zhang *Huahua Wei Huahua Wei *Guobao Wu Guobao Wu *Jian Jiang Jian Jiang *
  • Shangrao People's Hospital, Shangrao, Jiangxi Province, China

The final, formatted version of the article will be published soon.

    Objective: Observational studies have revealed a link between inflammatory bowel disease (IBD) and sarcopenia. However, it remains unclear whether this correlation between IBD and sarcopenia is causal. Methods: The genetic instrumental variables (IVs) associated with IBD and sarcopenia-related traits were derived from publicly available genome-wide association studies. We employed a two-sample bidirectional Mendelian randomization (MR) method. we obtained genetic IVs for five phenotypes from 34,652 cases in IBD, 27,432 cases in ulcerative colitis (UC), 212356 cases in crohn's disease (CD), 9336415 cases in low hand grip strength (LHGS), and 450243 cases in appendicular lean mass (ALM), respectively. The inverse variance weighting and other MR methods were used to explore the bidirectional causal relationship. Furthermore, we performed heterogeneity test, pleiotropy test, leave-one-out sensitivity test, and multivariate MR to evaluate the robustness of the the results. Results: The forward MR results showed that the UC (OR=0.994, 95% CI: 0.990.9876–1.000.9998, P = 0.044) and CD (OR=0.993, 95% CI: 0.9880.99–1.000.998, P = 0.006) was negatively correlated with ALM. In the reverse MR analysis, we also found that LHGS was negatively correlated with the IBD (OR=0.76, 95% CI: 0.61–0.94, P = 0.012) and CD (OR=0.53, 95% CI: 0.40–0.70, P <0.001). Besides, genetically predicted higher ALM reduced IBD (OR=0.87, 95% CI: 0.79–0.95, P = 0.002), UC (OR=0.84, 95% CI: 0.76–0.93, P = 0.001), and CD (OR=0.87, 95% CI: 0.77–0.99, P = 0.029). However, the results of other MR Analyses were not statistically different. Conclusions: We found genetically predicted UC and CD are causally associated with reduced ALM, and higher hand grip strength reduced IBD and CD risk, and higher ALM reduced IBDs risk. This MR study provides moderate evidence for a bidirectional causal relationship between IBD and sarcopenia.

    Keywords: inflammatory bowel disease, ulcerative colitis, Crohn's disease, sarcopenia-related traits, Mendelian randomization

    Received: 17 Mar 2024; Accepted: 01 Jul 2024.

    Copyright: © 2024 Sun, Liu, Xu, Zhang, Wei, Wu and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhihuang Sun, Shangrao People's Hospital, Shangrao, 334000, Jiangxi Province, China
    Guangwei Liu, Shangrao People's Hospital, Shangrao, 334000, Jiangxi Province, China
    Jiajia Xu, Shangrao People's Hospital, Shangrao, 334000, Jiangxi Province, China
    Xianyu Zhang, Shangrao People's Hospital, Shangrao, 334000, Jiangxi Province, China
    Huahua Wei, Shangrao People's Hospital, Shangrao, 334000, Jiangxi Province, China
    Guobao Wu, Shangrao People's Hospital, Shangrao, 334000, Jiangxi Province, China
    Jian Jiang, Shangrao People's Hospital, Shangrao, 334000, Jiangxi Province, China

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