AUTHOR=Han Li , Xu Shuling , Zhou Dongqi , Chen Rumeng , Ding Yining , Zhang Mengling , Bao Meihua , He Binsheng , Li Sen 

TITLE=Unveiling the causal link between metabolic factors and ovarian cancer risk using Mendelian randomization analysis

JOURNAL=Frontiers in Endocrinology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1401648

DOI=10.3389/fendo.2024.1401648

ISSN=1664-2392

ABSTRACT=<sec><title>Background</title><p>Metabolic abnormalities are closely tied to the development of ovarian cancer (OC), yet the relationship between anthropometric indicators as risk indicators for metabolic abnormalities and OC lacks consistency.</p></sec><sec><title>Method</title><p>The Mendelian randomization (MR) approach is a widely used methodology for determining causal relationships. Our study employed summary statistics from the genome-wide association studies (GWAS), and we used inverse variance weighting (IVW) together with MR-Egger and weighted median (WM) supplementary analyses to assess causal relationships between exposure and outcome. Furthermore, additional sensitivity studies, such as leave-one-out analyses and MR-PRESSO were used to assess the stability of the associations.</p></sec><sec><title>Result</title><p>The IVW findings demonstrated a causal associations between 10 metabolic factors and an increased risk of OC. Including “Basal metabolic rate” (OR= 1.24, <italic>P</italic>= 6.86×10<sup>-4</sup>); “Body fat percentage” (OR= 1.22, <italic>P</italic>= 8.20×10<sup>-3</sup>); “Hip circumference” (OR= 1.20, <italic>P</italic>= 5.92×10<sup>-4</sup>); “Trunk fat mass” (OR= 1.15, <italic>P</italic>= 1.03×10<sup>-2</sup>); “Trunk fat percentage” (OR= 1.25, <italic>P</italic>= 8.55×10<sup>-4</sup>); “Waist circumference” (OR= 1.23, <italic>P</italic>= 3.28×10<sup>-3</sup>); “Weight” (OR= 1.21, <italic>P</italic>= 9.82×10<sup>-4</sup>); “Whole body fat mass” (OR= 1.21, <italic>P</italic>= 4.90×10<sup>-4</sup>); “Whole body fat-free mass” (OR= 1.19, <italic>P</italic>= 4.11×10<sup>-3</sup>) and “Whole body water mass” (OR= 1.21, <italic>P</italic>= 1.85×10<sup>-3</sup>).</p></sec><sec><title>Conclusion</title><p>Several metabolic markers linked to altered fat accumulation and distribution are significantly associated with an increased risk of OC.</p></sec>