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SYSTEMATIC REVIEW article
Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 |
doi: 10.3389/fendo.2024.1399580
Depression, anxiety and self-esteem in adolescent girls with polycystic ovary syndrome: a systematic review and meta-analysis
Provisionally accepted- First Affiliated Hospital of Xiamen University, Xiamen, Fujian Province, China
Objective: Studies have shown the adverse psychological impact of polycystic ovary syndrome (PCOS), but the state of mental health in adolescents with PCOS remains unclear. Thus, we performed a systematic review and meta-analysis to investigate the prevalence and severity of depression and anxiety, as well as potential effects on self-esteem and quality of life (QoL) in this specific population. Methods: We systematically searched four electronic databases: PubMed, Embase, Web of Science, and the Cochrane Reviews database for articles published until 25/8/2024. We considered observational studies in which the subjects were adolescent girls with PCOS who had reported symptoms including anxiety, depression, self-esteem, and QoL. The Review Manager version 5.4 was used to analyze the available data extracted. We used the Newcastle-Ottawa Quality Assessment Scale (NOS) to evaluate the quality of selected studies. A funnel plot was utilized to assess the risk of literature bias, and a forest plot was used to represent the combined outcomes. This systematic review was previously registered in PROSPERO with the registration number CRD42022382036. Results: We included 11 studies in the systematic review and conducted meta-analyses on 10 of them. Adolescents with PCOS reported a higher risk of depression (OR = 2.21, 95% CI: 1.23 to 4.00, p = 0.008) and a higher level of depression scores (SMD = 0.43, 95% CI: 0.16 to 0.71, p = 0.002) than controls. There were no significant differences in anxiety (OR = 1.90, 95% CI: 0.52 to 6.96, p = 0.33; SMD = 0.19, 95% CI: -0.21 to 0.59, p = 0.36), self-esteem (SMD = -0.17, 95% CI: -0.85 to 0.52, p = 0.64), and QoL (SMD = -0.15, 95% CI: -0.42 to 0.11, p = 0.26) between the two groups. Conclusions: Our research indicated that adolescents with PCOS experienced more severe depressive symptoms than those without PCOS. This highlights the importance of evaluation and early treatment of mental health in PCOS. More clinicians should pay attention to the mental health of adolescent girls with PCOS through this study.
Keywords: Polycystic Ovary Syndrome, Adolescent, Depression, Anxiety, self-esteem
Received: 12 Mar 2024; Accepted: 10 Sep 2024.
Copyright: © 2024 Li, Zheng, Zhang, Lu, Guo, Chen and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xuanling Zheng, First Affiliated Hospital of Xiamen University, Xiamen, 361001, Fujian Province, China
Jinru Guo, First Affiliated Hospital of Xiamen University, Xiamen, 361001, Fujian Province, China
Fuhong Chen, First Affiliated Hospital of Xiamen University, Xiamen, 361001, Fujian Province, China
Changqin Liu, First Affiliated Hospital of Xiamen University, Xiamen, 361001, Fujian Province, China
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