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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Neuroendocrine Science
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1398691

Causal Relationships Between Plasma Lipidome and Diabetic Neuropathy: A Mendelian Randomization Study

Provisionally accepted
Xuejing Shao Xuejing Shao 1*Zhaoxiang Wang Zhaoxiang Wang 2Zhong Liu Zhong Liu 2Qichao Yang Qichao Yang 1Huibo Qiao Huibo Qiao 1Yong Yin Yong Yin 1Zhiyong Zhao Zhiyong Zhao 1
  • 1 Changzhou Wujin People's Hospital, Changning, China
  • 2 First People's Hospital of Kunshan, Kunshan, Jiangsu, China

The final, formatted version of the article will be published soon.

    Background: Dyslipidemia is closely related to diabetic neuropathy. This study examined the potential causal relationship involving 179 lipid species and the disease.The pooled data on 179 lipid species and diabetic neuropathy were obtained from previous genome-wide association studies (GWAS). A Mendelian Randomization (MR) method was employed to investigate the potential causal link, and the robustness of the findings was confirmed through comprehensive sensitivity analyses.Results: Genetically, phosphatidylcholine might be associated with the risk of diabetic neuropathy. Upon adjusting for multiple comparisons, higher levels of phosphatidylcholine (16:0_20:2) (OR = 0.82, 95%CI: 0.73-0.91; P < 0.001, FDR = 0.033) and phosphatidylcholine (16:1_18:1) (OR = 0.77, 95%CI: 0.67-0.88; P < 0.001, FDR = 0.019) are associated with a decreased risk of diabetic neuropathy. Further multivariable MR (MVMR) analysis demonstrated the effect of genetically predicted phosphatidylcholine (16:1_18:1) remained after adjusting for body mass index (BMI) and glycated hemoglobin (HbA1c). Sensitivity assessments have confirmed the robustness of these findings, revealing no evidence of heterogeneity or pleiotropy.Our research linked certain lipid species with diabetic neuropathy risk, suggesting that targeting lipids could be a therapeutic strategy in clinical trials addressing this condition.

    Keywords: Lipids, Diabetic neuropathy, GWAS, Mendelian Randomization Analysis, causal relationship

    Received: 10 Mar 2024; Accepted: 27 Dec 2024.

    Copyright: © 2024 Shao, Wang, Liu, Yang, Qiao, Yin and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xuejing Shao, Changzhou Wujin People's Hospital, Changning, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.