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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Endocrinology of Aging
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1398235
This article is part of the Research Topic Endocrinology of Obesity, Aging and Stress View all 12 articles

Relationship Between Triglyceride-Glucose Index and Cognitive Function Among Community-Dwelling Older Adults: A Population-Based Cohort Study

Provisionally accepted
Weimin Bai Weimin Bai 1Shuang An Shuang An 2Hui Jia Hui Jia 3Juan Xu Juan Xu 4Lijie Qin Lijie Qin 1*
  • 1 Henan Provincial People's Hospital, Zhengzhou, Henan Province, China
  • 2 Department of Pediatric Rehabilitation Medicine, Children’s Hospital Affiliated of Zhengzhou University, Zhengzhou, China
  • 3 Navy Qingdao Special Service Recuperation Center, Qingdao, China
  • 4 Department of General Surgery, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, China

The final, formatted version of the article will be published soon.

    The global increase in the aging population presents considerable challenges, particularly regarding cognitive impairment, a major concern for public health. This study investigates the association between the triglyceride-glucose (TyG) index, a measure of insulin resistance, and the risk of cognitive impairment in the elderly.Methods: This prospective cohort study enrolled 2,959 participants aged 65 and above from the 2015 and 2020 waves of the China Health and Retirement Longitudinal Study (CHARLS). The analysis employed a logistic regression model to assess the correlation between the TyG index and cognitive impairment.The study included 2,959 participants, with a mean age of 71.2 ± 5.4 years, 49.8% of whom were female. The follow-up in 2020 showed a decrease in average cognitive function scores from 8.63 ± 4.61 in 2015 to 6.86 ± 5.45. After adjusting for confounding factors, a significant association was observed between TyG index quartiles and cognitive impairment. Participants in the highest quartile (Q4) of baseline TyG had a higher risk of cognitive impairment compared to those in the lowest quartile (Q1) (odds ratio [OR]: 1.97, 95% confidence intervals [CI]: 1.28-2.62, P<0.001).The study highlights a significant connection between elevated TyG index levels and cognitive impairment among older adults in China. These findings suggest that targeted interventions to reduce the TyG index could mitigate cognitive impairment and potentially lower the incidence of dementia.

    Keywords: triglyceride glucose, cognitive impairment, Elderly, Insulin Resistance, CHARLS

    Received: 09 Mar 2024; Accepted: 08 Jul 2024.

    Copyright: © 2024 Bai, An, Jia, Xu and Qin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lijie Qin, Henan Provincial People's Hospital, Zhengzhou, 450000, Henan Province, China

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