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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1397423
This article is part of the Research Topic Women in Clinical Diabetes View all 14 articles

Association Between Genetic Polymorphisms and Gestational Diabetes Mellitus Susceptibility in a Chinese Population

Provisionally accepted
Qiaoli Zeng Qiaoli Zeng 1Jia Liu Jia Liu 1Xin Liu Xin Liu 1Na Liu Na Liu 1Weibiao Wu Weibiao Wu 1Watson Gyan Watson Gyan 1Dehua Zou Dehua Zou 2Yue Wei Yue Wei 1Runmin Guo Runmin Guo 1*
  • 1 Shunde Women and Children’s Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong Province, China
  • 2 School of Pharmacy, Macau University of Science and Technology, Macau SAR, China, Macau SAR, China

The final, formatted version of the article will be published soon.

    Background: Although the association between HHEX, IGF2BP2, and FTO polymorphisms and the risk of GDM has been investigated in several studies, the findings have been inconsistent across different populations. The study aimed to investigate the association between genetic polymorphisms and GDM risk in a Chinese population.Methods: 502 control volunteers and 500 GDM patients were enrolled. IGF2BP2 rs11705701 and rs4402960, FTO rs9939609, and HHEX rs1111875 and rs5015480 were all genotyped using the SNPscan TM genotyping assay. The independent sample t-test, logistic regression, and chi-square test were used to assess the variations in genotype and allele and their relationships with the risk of GDM. The blood glucose level, gestational week of delivery, and newborn weight were compared using a one-way ANOVA.Results: After adjusting for confounding factors, the results show that the rs1111875 heterozygous (OR=1.370; 95% CI: 1.040-1.805; P = 0.025) and overdominant (OR=1.373; 95% CI: 1.049-1.796; P = 0. 021) models are significantly associated with an increased risk of GDM, especially for the age ≥ 30 years group:

    Keywords: gestational diabetes mellitus, rs1111875, rs5015480, rs11705701, rs4402960, rs9939609, case-control study

    Received: 07 Mar 2024; Accepted: 13 Nov 2024.

    Copyright: © 2024 Zeng, Liu, Liu, Liu, Wu, Gyan, Zou, Wei and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Runmin Guo, Shunde Women and Children’s Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong Province, China

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