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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Renal Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1391891
This article is part of the Research Topic The Relationship Between Gut Microbiota and Metabolic Diseases View all 4 articles

Elucidating the Causal Relationship Between Gut Microbiota, Metabolites, and Diabetic Nephropathy in European Patients: Revelations from Genome-wide Bidirectional Mendelian Randomization Analysis

Provisionally accepted
Siyuan Song Siyuan Song *Jiangyi Yu Jiangyi Yu *
  • Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China

The final, formatted version of the article will be published soon.

    Previous observational studies suggest a potential link between gut microbiota, metabolites, and diabetic nephropathy. However, the exact causal relationship among these factors remains unclear.We conducted a two-sample bidirectional Mendelian randomization study using summary statistics from the IEU OpenGWAS Project database to investigate gut microbiota, metabolites, and diabetic nephropathy. A range of methods, including inverse variance weighting, MR-Egger, weighted median, and simple median, were applied to examine causal associations. Sensitivity analyses were performed to assess the robustness of the results. Additionally, reverse Mendelian randomization analysis was conducted, treating significant gut microbiota as the outcome, to evaluate effects and perform sensitivity testing. This comprehensive approach provided an in-depth assessment of the interactions among gut microbiota, metabolites, and diabetic nephropathy.

    Keywords: Mendelian Randomization Analysis, Gut Microbiota, Metabolites, diabetic nephropathy, bidirectional

    Received: 26 Feb 2024; Accepted: 17 Dec 2024.

    Copyright: © 2024 Song and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Siyuan Song, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China
    Jiangyi Yu, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China

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