The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 15 - 2024 |
doi: 10.3389/fendo.2024.1390778
Adipose Tissue Insulin Resistance in Young Japanese Women is Associated with Metabolic Abnormalities and Dehydroepiandrosterone-sulfate
Provisionally accepted- School of Medicine, Juntendo University, Bunkyō, Tokyo, Japan
The proportion of young Japanese women who are underweight is exceptionally high. We previously showed that the prevalence of impaired glucose tolerance (IGT) was high in underweight young Japanese women, and that IGT was characterized by high free fatty acid levels and adipose tissue insulin resistance (ATIR).As the next step, this study aimed to explore factors associated with elevated ATIR in this population.Participants: Ninety-eight young, healthy, underweight women participated in this study.To investigate the relationship between ATIR and metabolic parameters, participants were divided into three groups (Low, Medium, and High) according to ATIR level. Body composition examination, oral glucose tolerance testing, and blood biochemical analysis were performed; Adipo-IR and the Matsuda index were used as indices of ATIR and systemic insulin sensitivity, respectively.Results: Participants in the High ATIR group had the highest prevalence of IGT (25%), and significantly higher body fat percentage, whole-body insulin resistance, and levels of insulin-like growth factor-1 and dehydroepiandrosterone sulfate (DHEA-S) than the other two groups. They were also significantly younger and had higher systolic blood pressure than the Low ATIR group. Multiple regression analysis showed that DHEA-S, which is known to enhance lipolysis in adipose tissue, was an independent correlate of ATIR.Conclusions: Underweight Japanese women with high ATIR had impaired metabolism, a higher prevalence of IGT, higher systemic insulin resistance, and higher systolic blood pressure. DHEA-S was a determinant of high ATIR levels.
Keywords: underweight young women, Adipose tissue insulin resistance, Impaired glucose tolerance, metabolic abnormality, Dehydroepiandrosterone-sulfate
Received: 23 Feb 2024; Accepted: 29 Aug 2024.
Copyright: © 2024 Sato, Tamura, Kaga, Yamasaki, Kadowaki, Sugimoto, Nakagata, Someya, Nishida, Kawamori and Watada. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yoshifumi Tamura, School of Medicine, Juntendo University, Bunkyō, 113-8421, Tokyo, Japan
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.