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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1390035
This article is part of the Research Topic Advances in the Research of Diabetic Retinopathy, Volume III View all 11 articles

Relationship of fibroblast growth factor 21, Klotho, and diabetic retinopathy: A Meta-analysis

Provisionally accepted
Yanhua Jiang Yanhua Jiang 1Weilai Zhang Weilai Zhang 1Yao Xu Yao Xu 2Xiandong Zeng Xiandong Zeng 1*Xin Sun Xin Sun 3*
  • 1 The Fourth People's Hospital of Shenyang, Shenyang, Liaoning Province, China
  • 2 Suzhou Dushu Lake Hospital, Suzhou, China
  • 3 The First Affiliated Hospital of Soochow University, Suzhou, China

The final, formatted version of the article will be published soon.

    Background: Diabetic retinopathy (DR) is a serious microvascular complication of diabetes mellitus. Research has identified a close relationship between fibroblast growth factor 21 (FGF21) and DR. FGF21 is a member of the FGF subfamily, which is activated by the Klotho coenzyme involved in the occurrence of DR. However, the association between FGF21, Klotho, and DR remains controversial.Aim: To assess FGF21 and Klotho levels in patients with DR.Methods: A literature search of the Web of Science, Wiley Online Library, PubMed, China National Knowledge Infrastructure and Wanfang databases was performed. The title or abstract search terms "diabetic retinopathy" and "DR" were used in combination with "fibroblast growth factor 21", "FGF21", and "Klotho". Meta-analysis results are presented as standardized mean difference (SMD) with corresponding 95% confidence interval (CI).Results: Fifteen studies were included in this meta-analysis. FGF21 levels in patients with DR were significantly higher than in non-DR patients with diabetes (SMD: 2.12, 95% CI [1.40, 2.84]). Klotho levels in patients with DR were significantly lower than in non-DR patients with diabetes (SMD: -0.63, 95% CI [-1.22, -0.04]).This systematic review is the first to evaluate the relationship between FGF21, Klotho levels, and DR. FGF21 levels were significantly higher in patients with DR. Fully elucidating the role of FGF21 will significantly contribute to the treatment of DR.

    Keywords: FGF21, Klotho, Diabetic Retinopathy, fibroblast growth factor 21, Dr

    Received: 22 Feb 2024; Accepted: 08 Aug 2024.

    Copyright: © 2024 Jiang, Zhang, Xu, Zeng and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiandong Zeng, The Fourth People's Hospital of Shenyang, Shenyang, Liaoning Province, China
    Xin Sun, The First Affiliated Hospital of Soochow University, Suzhou, China

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