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REVIEW article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1390013

Broadening Horizons: The Role of Ferroptosis in Polycystic Ovary Syndrome

Provisionally accepted
Min Wang Min Wang 1Boqi zhang Boqi zhang 2*Shuai Ma Shuai Ma 1XU YING XU YING 1Donghai zhao Donghai zhao 3*Jingshun Zhang Jingshun Zhang 1*Chunjin Li Chunjin Li 2*Xu Zhou Xu Zhou 2*Lianwen Zheng Lianwen Zheng 1*
  • 1 Department of Obstetrics and Gynecology, Second Hospital of Jilin University, Changchun, China
  • 2 College of Animal Science, Jilin University, Changchun, Jilin Province, China
  • 3 Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin Province, China

The final, formatted version of the article will be published soon.

    Polycystic ovarian syndrome (PCOS) is a common heterogeneous reproductive endocrine metabolic disorder in women of reproductive age characterized by clinical and biochemical hyperandrogenaemia, ovulation disorders, and polycystic ovarian morphology. Ferroptosis is a novel type of cell death driven by iron accumulation and lipid peroxidation. Ferroptosis plays a role in maintaining redox balance, iron metabolism, lipid metabolism, amino acid metabolism, mitochondrial activity, and many other signalling pathways linked to diseases. Iron overload is closely related to insulin resistance, decreased glucose tolerance, and the occurrence of diabetes mellitus. There is limited research on the role of ferroptosis in PCOS. Patients with PCOS have elevated levels of ferritin and increased reactive oxygen species in ovarian GCs. Studying ferroptosis in PCOS patients is highly important for achieving personalized treatment. This article reviews the progress of research on ferroptosis in PCOS, introduces the potential connections between iron metabolism abnormalities and oxidative stress-mediated PCOS, and provides a theoretical basis for diagnosing and treating PCOS.

    Keywords: ferroptosis, Polycystic Ovary Syndrome, Oxidative Stress, metabolic disorders, Expression, biomarkers

    Received: 22 Feb 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Wang, zhang, Ma, YING, zhao, Zhang, Li, Zhou and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Boqi zhang, College of Animal Science, Jilin University, Changchun, Jilin Province, China
    Donghai zhao, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, Jilin Province, China
    Jingshun Zhang, Department of Obstetrics and Gynecology, Second Hospital of Jilin University, Changchun, China
    Chunjin Li, College of Animal Science, Jilin University, Changchun, Jilin Province, China
    Xu Zhou, College of Animal Science, Jilin University, Changchun, Jilin Province, China
    Lianwen Zheng, Department of Obstetrics and Gynecology, Second Hospital of Jilin University, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.