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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1389538
This article is part of the Research Topic Physical Exercise and Diabetes: Exploring the Relationship and Impact on Health Outcome View all 9 articles

Impact of Diverse Aerobic Exercise Plans on Glycemic Control, Lipid Levels, and Functional Activity in Stroke Patients with Type 2 Diabetes Mellitus

Provisionally accepted
Kangcheng Chen Kangcheng Chen 1Yulong Wang Yulong Wang 2Dongxia Li Dongxia Li 2*Jun LI Jun LI 1*Yong Huang Yong Huang 2*Meiling Huang Meiling Huang 2*Haifeng Ma Haifeng Ma 1*
  • 1 Shanghai University of Sport, Shanghai, China
  • 2 Department of Rehabilitation, Shenzhen Second People’s Hospital, Shenzhen, China

The final, formatted version of the article will be published soon.

    Aims: This study aimed to assess the effects of Low-to-Moderate Intensity Continuous Training (LMICT), Moderate-Intensity Interval Training (MIIT), and Reduced-Exertion High-Intensity Training (REHIT) on blood glucose regulation, functional recovery, and lipid levels in individuals who have experienced a stroke and are diagnosed with Type 2 Diabetes Mellitus (T2DM). Methods: A total of fortyForty-two T2DM stroke patients were randomly allocated to four groups: LMICT, MIIT, REHIT, and a control group (CON). Participants continuously monitored their blood glucose levels throughout the intervention using continuous glucose monitoring (CGM) devices. The study comprised two exercise intervention cycles: the first lasting from Day 3 to Day 14 and the second from Day 15 to Day 28, with the initial two days serving as contrasting periods. Primary outcomes encompassed CGMderived blood glucose measurements, the Barthel Index (BI), Fugl-Meyer Assessment lower-extremity subscale (FMA-LE), as well asand alterations in triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c). Results: The study revealed that, comparedCompared towith the CON, the MIIT group showed significant improvements in mean glucose (MG), glucose standard deviation (SD), time above range (TAR), and time in range (TIR); ). Thethe REHIT group exhibited significantly reduced time below range (TBR), glucose SD, and coefficient of variation (CV). Regarding lipid levels improvement, although the REHIT group significantly loweredachieved a significant reduction in triglyceride (TG) levels compared to with the CON overall, the overall effects of LMICT, MIIT, and REHIT on lipid profiles were relatively modest. RegardingConcerning functional recovery, the REHIT group significantly improved the Barthel Index (BI) and Fugl-Meyer Assessment for lower extremities ( FMA-LE). Conclusion: Although the shortterm quantitative impact of exercise on lipid levels may be limited, both REHIT and MIIT significantly improved glycemic management and reduced glucose variability in post-stroke patients with Type 2 Diabetes Mellitus. Additionally, REHIT notably enhanced functional recovery.

    Keywords: Stroke, type 2 diabetes mellitus, Aerobic exercise training, Continuous glucose monitoring, Glycemic variability, Functional activity, Lipid levels

    Received: 13 Mar 2024; Accepted: 28 Aug 2024.

    Copyright: © 2024 Chen, Wang, Li, LI, Huang, Huang and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Dongxia Li, Department of Rehabilitation, Shenzhen Second People’s Hospital, Shenzhen, China
    Jun LI, Shanghai University of Sport, Shanghai, China
    Yong Huang, Department of Rehabilitation, Shenzhen Second People’s Hospital, Shenzhen, China
    Meiling Huang, Department of Rehabilitation, Shenzhen Second People’s Hospital, Shenzhen, China
    Haifeng Ma, Shanghai University of Sport, Shanghai, China

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